SitemapImpressumDatenschutzerklärungdeutschenglish
MHH Logo
Medizinische Hochschule Hannover | Carl-Neuberg-Str.1 | 30625 Hannover | Tel.:(+49) 0511-532-0

Publications

2013

 

Wang, Q., Lu, J., Zhang, S., Wang, S., Wang, W., Wang, B., Wang, F., Chen, Q., Duan, E., Leitges, M., Kispert, A., Wang, H. (2013). Wnt6 is essential for stromal cell proliferation during decidualization. Biol Reprod. 88, 5.

 

Lüdtke, T.H.-W., Farin, H.F., Rudat, C., Schuster-Gossler, K., Petry M., Barnett, P., Christoffels, V.M., Kispert, A. (2013) Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b. PLoS Genet. 9, e1003189.

 

Mommersteeg, M.T., Andrews, W.D., Ypsilanti, A.R., Zelina, P., Yeh, M.L., Norden, J., Kispert, A., Chedotal, A., Christoffels, V.M., Parnavelas, J.G. (2013). Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium. Circ. Res. 112, 465-475.

 

Farin, H.F., Lüdtke, T.H.-W., Schmidt, M.K., Placzko, S., Schuster-Gossler, K., Christoffels, V.M., Kispert, A. (2013). Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin. PLoS Genet. 9, e1003467.

 

Martin, E., Caubit, X., Airik, R., Vola, C., Fatmi, A., Kispert, A., Fasano, L. (2013). TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing Myocardin activity. PLoS One 8, e63721.

 

Trowe, M.-O., Zhao, L., Weiss, A.-C., Christoffels, V., Epstein, D., Kispert, A. (2013). Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for the formation of the neurohypophysis. Development 140, 2299-2309.

 

Bohnenpoll, T., Bettenhausen, E., Weiss, A.-C., Foik, A.B., Trowe, M.-O., Blank, P., Airik, R., Kispert, A. (2013). Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Dev. Biol. 380, 25-36.

 

Seidl, S., Braun, U., Roos, N., Li, S., Lüdtke, T.H., Kispert, A.*, Leitges, M.* (2013). Phenotypical Analysis of Atypical PKCs In Vivo Function Display a Compensatory System at Mouse Embryonic Day 7.5. PLoS One 8, e62756. *shared last authorship.

 

Greulich, F., Kispert, A. (2013). Epicardial Lineages. J. Dev. Biol. 1, 32-46.

 

Kispert, A. (2013). T-Box-Gene in der frühen Herzentwicklung. VBio-Rundbrief der Landesverbände Nord.

 

Rudat, R., Norden, J., Taketo, M.M., Kispert, A. (2013). Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2- and Pdgfra-signaling. Cardiovasc. Res.  100, 411-421.

 

Schaale, K., Brandenburg, J., Kispert, A., Leitges, M., Ehlers, S., Reiling, N. (2013). Wnt6 is expressed in granulomatous lesions of M. tuberculosis infected mice and is involved in macrophage differentiation and proliferation. J. Immunol. 191, 5182-5195.

 

 

2012

 

Kispert, A. (2012). No muscle for a damaged heart: Thymosin beta 4 treatment after myocardial infarction does not induce myocardial differentiation of epicardial cells. J. Mol. Cell. Card. 52, 10-12.

 

Völker LA, Petry M, Abdelsabour-Khalaf M, Schweizer H, Yusuf F, Busch T, Schermer B, Benzing T, Brand-Saberi B, Kretz O, Höhne M, Kispert A. (2012). Comparative analysis of Neph gene expression in mouse and chicken development. Histochem. Cell. Biol. 137, 355-366.

 

Singh, R., Hoogaars, W.M., Barnett, P., Grieskamp, T., Rana, M.S., Buermans, H., Farin, H.F., Petry, M., Heallen, T., Martin, J.F., Moorman, A.F., 't Hoen, P.A., Kispert, A., Christoffels, V.M. (2012). Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell. Mol. Life Sci. 69, 1377-1389.

 

Kispert, A. and Gossler, A. (2012). Early mouse development. In: The Laboratory mouse, 2nd edition, Ed. by H. Hedrich. Academic Press, San Diego.

 

Rudat, C., Kispert, A. (2012). Wt1 and epicardial fate mapping. Circ. Res. 111, 165-169.

 

Trowe, M.-O., Airik, R., Weiss, A.-C., Farin, H.F., Foik, A.B., Bettenhausen, E., Schuster-Gossler, K., Taketo, M.M., Kispert, A. (2012). Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter. Development 139, 3099-3108.

 

Norden, J., Grieskamp, T., Christoffels, V.M., Moorman, A.F.M., Kispert, A. (2012). Partial Absence of Pleuropericardial Membranes in Tbx18- and Wt1-Deficient mice. PLoS One. 7, e45100.

 

Norden, J., Kispert, A. (2012). Wnt/Ctnnb1-Signaling and the Mesenchymal Precursor Pools of the Heart. Trends Cardiovasc. Med. 22, 118-122.

 

Greulich, F., Farin, H.F., Schuster-Gossler, K., Kispert, A. (2012). Tbx18 function in epicardial development. Cardiovasc. Res. 96, 476-483.

 

Rabe, T.I., Griesel, G., Blanke S., Kispert, A., Leitges, M., van der Zwaag B., Burbach, J.P., Varoqueaux, F., Mansouri A. (2012). The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Dev. 7, 39.

 

 

2011

 

Merveille AC, Davis EE, Becker-Heck A, Legendre M, Amirav I, Bataille G, Belmont J, Beydon N, Billen F, Clément A, Clercx C, Coste A, Crosbie R, de Blic J, Deleuze S, Duquesnoy P, Escalier D, Escudier E, Fliegauf M, Horvath J, Hill K, Jorissen M, Just J, Kispert A, Lathrop M, Loges NT, Marthin JK, Momozawa Y, Montantin G, Nielsen KG, Olbrich H, Papon JF, Rayet I, Roger G, Schmidts M, Tenreiro H, Towbin JA, Zelenika D, Zentgraf H, Georges M, Lequarré AS, Katsanis N, Omran H, Amselem S. (2011). CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat Genet. 43, 72-78.

 

Froese, N., Kattih, B., Breitbart, A., Grund, A., Geffers, R., Molkentin, J.D., Kispert, A., Wollert, K.C., Drexler, H., Heineke, J. (2011). GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor Beta/Activin Receptor-Like Kinase 5 Signaling. J. Biol. Chem.286, 5680-5690.

 

Grieskamp, T., Rudat, C., Lüdtke, T.H., Norden, J., Kispert, A. (2011). Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ. Res. 108, 813-823.

 

Heeringa SF, Chernin G, Chaki M, Zhou W, Sloan AJ, Ji Z, Xie LX, Salviati L, Hurd TW, Vega-Warner V, Killen PD, Raphael Y, Ashraf S, Ovunc B, Schoeb DS, McLaughlin HM, Airik R, Vlangos CN, Gbadegesin R, Hinkes B, Saisawat P, Trevisson E, Doimo M, Casarin A, Pertegato V, Giorgi G, Prokisch H, Rötig A, Nürnberg G, Becker C, Wang S, Ozaltin F, Topaloglu R, Bakkaloglu A, Bakkaloglu SA, Müller D, Beissert A, Mir S, Berdeli A, Varpizen S, Zenker M, Matejas V, Santos-Ocaña C, Navas P, Kusakabe T, Kispert A, Akman S, Soliman NA, Krick S, Mundel P, Reiser J, Nürnberg P, Clarke CF, Wiggins RC, Faul C, Hildebrandt F. (2011). COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin. Invest. 121, 2013-2024.

 

Greulich, F., Rudat, C., Kispert, A. (2011). Mechanisms of T-box functions in the heart. Cardiovasc. Res. 91, 212-222.

 

Norden, J., Greulich, F., Rudat, C., Taketo, M.M.,, Kispert, A. (2011). Wnt/ß-Catenin Signaling Maintains the Mesenchymal Precursor Pool for Murine Sinus Horn Formation. Circ. Res. 109, e42-e50.  

 

Trowe, M.-O., Maier, H., Petry, M., Schweizer, M., Schuster-Gossler, K., Kispert, A. (2011). Impaired stria vascularis integrity upon loss of E-cadherin in basal cells. Dev. Biol. 359, 95-107.

 

 

2010

 

Louie, C.M., Caridi, G., Lopes,V.S., Brancati, F., Kispert, A., Lancaster, M.A., Schlossman, A.M., Otto, E.A., Leitges, M., Gröne, H.J., Lopez, I., Gudiseva, H.V., O'Toole, J.F., Vallespin, E., Ayyagari, R., Ayuso, C., Cremers, F.P., den Hollander, A.I., Koenekoop, R.K., Dallapiccola, B., Ghiggeri, G.M., Hildebrandt, F., Valente, E.M., Williams, D.S., Gleeson, J.G. (2010). AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat. Genet. 42, 175-180.

 

Christoffels, V.M., Smits, G.J., Kispert, A., Moorman, A.F.M. (2010). Development of the pacemaker tissues of the heart. Circ. Res 106, 240-254.

 

Norden, J., Grieskamp, T., Lausch, E., van Wijk, B., van den Hoff, M.J.B., Englert, E., Petry, M., Mommersteeg, M.T.M., Christoffels, V.M., Niederreither, K., Kispert, A. (2010). Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns. Circ. Res., 106, 1212-1220.

 

Trowe, M.O., Shah, S., Petry, M., Airik, R., Schuster-Gossler, K., Kist., R., Kispert, A. (2010). Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse. Dev. Biol 342, 51-62.

 

Mommersteeg, M.T.M., Dominguez, J.N., Wiese, C., Norden, J., de Gier-de Vries, C., Burch, J.B.E., Kispert, A., Brown, N.A., Moorman, A.F.M., Christoffels, V.M. (2010). The sinus venosus progenitors separate and diversify from the first and second heart fields early in development. Cardiovasc. Res. 87, 92-101

 

Aanhaanen, W.T., Mommersteeg, M.T., Norden, J., Wakker, V., de Gier-de Vries, C., Anderson ,R.H., Kispert, A., Moorman, A.F., Christoffels, V.M. (2010). Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart. Circ. Res 107, 728-736.

 

Landgraf, K., Bollig, F., Trowe, M.-O., Besenbeck, B., Ebert, C., Kruspe, D., Kispert, A., Hänel, F., and Christoph Englert, C. (2010). Sipl1 and Rbck1 are novel Eya1-binding proteins with a role 1 in craniofacial development. Mol. Cell. Biol. 30, 5764-5775.

 

Airik, R., Trowe, M.O., Foik, A., Farin, H.F., Petry, M., Schuster-Gossler, K., Schweizer, M., Scherer, G., Kist, R., Kispert, A. (2010). Hydroureternephrosis due to loss of Sox9 regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum. Mol. Genet 19, 4918-4929. 

 

Singh, R., Kispert, A. (2010). Tbx20, Smads and the atrioventricular canal. Trends Cardiovasc. Med., 20, 109-114.

 


2009

 

Wiese, C.*, Grieskamp, T.*, Airik, R., Mommersteeg, M.T., Gardiwal, A., de Gier-de Vries C., Schuster-Gossler, K., Moorman, A.F., Kispert, A.*, Christoffels, V.M. * (2009). Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3. Circ. Res. 104, 388-397. * equal contribution.

 

Lüdtke, T., Christoffels, V.M., Petry, M., Kispert, A. (2009). Tbx3 Promotes Liver Bud Expansion During Mouse Development by Suppression of Cholangiocyte Differentiation. Hepatalogy 49, 969-978.

 

Christoffels, V.M., Grieskamp, T., Norden, J., Mommersteeg, M.T.M., Rudat, C., Kispert, A. (2009). Tbx18 and the fate of epicardial Progenitors. Nature 458, E8-E9.

 

Aanhaanen, W.T., Brons, J.F., Domínguez, J.N., Rana, M.S., Norden, J., Airik, R., Wakker, V., de Gier-de Vries, C., Brown, N.A., Kispert, A., Moorman, A.F., Christoffels, V.M. (2009). The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ. Res. 104, 1267-1274.

 

Singh, R*, Horsthuis, T.*, Farin, H.F., Grieskamp, T., Norden, J., Petry, M., Wakker, V., Moorman, A.F., Christoffels, V.M.*, Kispert. A.* (2009). Tbx20 interacts with Smads to confine Tbx2 expression to the atrioventricular canal. Circ. Res. 105, 442-452. * equal contribution.

 

Zirzow, S., Lüdtke, T.-H., Brons, J.F., Petry, M., Christoffels, V.M., Kispert, A. (2009). Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev. Biol 336, 145-155.

 

Tao, B., Bu, S., Yang, Z., Siroky, B., Kappes, J.C., Kispert, A., Guay-Woodford, L. (2009). Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J. Am. Soc. Nephrol. 20, 2570-2580.

Loges, N.T., Olbrich, H., Becker-Heck, A., Häffner, K., Heer, A., Reinhard, C., Schmidts, M., Kispert, A., Zariwala, M.A., Leigh, M.W., Knowles, M.R., Zentgraf, H., Seithe, H., Nürnberg, G., Nürnberg, P., Reinhardt, R., Omran, H. (2009). Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. Am. J. Hum. Gen. 85, 883-889.

Christoffels, V.M., Grieskamp, T., Norden, J., Mommersteeg, M.T.M., Rudat, C., Kispert, A. (2009). Tbx18 and the fate of epicardial progenitors. Nature 458, E8-9.

Lüdtke, T., Christoffels, V.M., Petry, M., Kispert, A. (2009). Tbx3 Promotes Liver Bud Expansion During Mouse Development by Suppression of Cholangiocyte Differentiation. Hepatalogy 49, 969-978.

Kobayashi, K., Luo, M., Zhang, Y., Wilkes, D.C., Ge, G., Grieskamp, T., Yamada, C., Liu, T.C., Huan,g G., Basson, C.T., Kispert, A., Greenspan, D.S., Sato, T.N. (2009). Secreted Frizzled Related Protein 2: a novel procollagen C-proteinase enhancer with a key role in myocardial infarction-associated fibrosis. Nature Cell Biol. 11, 46-55.

Wiese, C.*, Grieskamp, T.*, Airik, A., Mommersteeg, M.T.M., Gardiwal, A., de Gier-de Vries, C., Schuster-Gossler, K., Moorman, A.F.M., Kispert, A.*, Christoffels, V.M.* (2009). Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3. Circ. Res. 104, 388-397.  * equal contribution


2008

Winkler, M.E., Mauritz, C., Groos, S., Kispert, A., Menke, S., Hoffmann, A., Gruh, I., Schwanke, K., Haverich, A., Martin, U. (2008). Serum-free differentiation of murine embryonic stem cells into alveolar type II epithelial cells. Cloning Stem Cells 10, 49-64.

Potok, M.A., Cha, K.B., Hunt, A., Brinkmeier, M.L., Leitges, M., Kispert, A. and Camper, S.A. (2008). WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev. Dyn. 237, 1006-1020.

Bergmann, C., Fliegauf, M., Bruechle, N.O., Frank, V., Olbrich, H., Kirschner, J., Schermer, B., Schmedding, I., Kispert, A., Kränzlin, B., Nürnberg, G., Becker, C., Grimm, T., Girschick, G., Lynch, S.A., Kelehan, P., Senderek, J., Neuhaus, T.J., Stallmach, T., Zentgraf, H., Nürnberg, P., Gretz, N., Lo, C., Lienkamp, S., Schäfer, T., Walz, G., Benzing, T., Zerres, K., Omran, H. (2008). Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am. J. Hum. Genet. 82, 959-970.

Trowe, O., Maier, H., Schweizer, M., Kispert, A. (2008). Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes. Development 135, 1725-1734.

Farin, H.F., Mansouri, A., Petry, M., Kispert, A. (2008). T-box Protein Tbx18 Interacts with the Paired Box Protein Pax3 in the Development of the Paraxial Mesoderm. J. Biol. Chem.  283, 25372-25380.

Lausch, E., Hermanns, P., Farin, H.F., Alanay, Y., Unger, S., Nikkel, S., Steinwender, C., Scherer, G., Spranger, J., Zabel, B., Kispert, A., Superti-Furga, A. (2008). TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome. Am. J. Hum. Genet. 83, 649-655.


2007

Kaelin, R.E., Kretz, M.P., Meyer, A.M., Kispert, A., Heppner, F.L. and Brändli, A.W. (2007). Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev. Biol. 305, 599-614.

Wittler, L., Shin, E.-h., Grote, P., Kispert, A., Beckers, A., Gossler, A., Werber, M., and Herrmann, B.G. (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signaling and Tbx6. EMBO Reports 8, 784-789.

Farin, H.F., Bussen, M., Schmidt, M.K., Singh, M.K., Schuster-Gossler, K. and Kispert, A. (2007). Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. J. Biol. Chem. 282, 25748-25759.

Reggiani, L., Raciti, D., Airik, R., Kispert, A. and Brändli, A.W. (2007). The prepattern transcription factor Irx3 directs nephron segment identity. Genes Dev. 21, 2358-2370.

Andreou, A.M., Pauws, E., Jones, M.C., Singh, M.K., Bussen, M., Doudney, K., Moore, G.E., Kispert, A., Brosens, J.J. and Stanier, S. (2007). TBX22 missense mutations found in X-linked cleft palate (CPX) patients affect DNA binding, sumoylation and transcriptional repression. Am. J. Hum. Gen. 81, 700-712.

Airik, R. and Kispert, A.  (2007). Down the tube of obstructive nephropathies: the importance of tissue interactions in ureter development.  Kidney Int. 72, 1459-1467.


2006

Osafune, K., Takasato, M., Kispert, A., Asashima, M. and Nishinakamura, R. (2006). Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development 133, 151-161.

Sass, J.O., Mohr, V., Olbrich, H., Engelke, U., Horvath, J., Fliegauf, M., Loges, N.T., Schweitzer-Krantz, S., Moebus, R., Weiler, P., Kispert, A., Superti-Furga, A., Wevers, R.A. and Omran, H. (2006).  Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism. Am. J. Hum. Genetics 78, 401-409.

Airik, R., Bussen, M., Singh, M.K., Petry, M. and Kispert, A. (2006). Tbx18 regulates the development of the ureteral mesenchyme. J. Clin. Invest. 116, 663-674.

Jochheim-Richter, A., Rüdrich, U., Koczan, D., Hillemann, T., Tewes, S., Petry, M., Kispert, A., Deep Sharma, A., Attaran, F., Manns, M.P. and Ott, M. (2006). Gene expression analysis identifies novel genes participating in early murine liver development and adult liver regeneration. Differentiation 74, 167-173.

Sayer, J.A., Otto, E.A., O'toole, J.F., Nurnberg, G., Kennedy, M.A., Becker, C., Hennies, H.C., Helou, J., Attanasio, M., Fausett, B.V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R.G., Allen, S.J., Wilkinson, C.J., Nigg, E.A., Shou, C., Lillo, C., Williams, D.S., Hoppe, B., Kemper, M.J., Neuhaus, T., Parisi, M.A., Glass, I.A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M.R. and Hildebrandt, F. (2006). The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat. Genet. 38, 674-681.

Franco, D., Meilhac, S.M., Christoffels, V.M., Kispert, A., Buckingham, M. and Kelly, R.G. (2006). Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart. Dev. Biol. 294, 366-375.

Christoffels, V.M., Mommersteeg, M.T.M., Trowe, M.-O., Prall, O.W.J., de Gier-de Vries, C., Soufan, A.T., Bussen, M., Schuster-Gossler, K., Harvey, R.P., Moorman, A.F.M. and Kispert, A. (2006). Formation of the venous pole of the heart from an Nkx2.5-negative precursor population requires Tbx18. Circ. Res. 98, 1555-1563.

Barrionuevo, F., Taketo, M.M., Scherer, G. and Kispert, A. (2006). Sox9 is required for notochord maintenance in mice. Dev. Biol. 295, 128-140.

Gerke, P., Benzing, T., Höhne, M., Kispert, A., Frotscher, M., Walz, G. and Kretz, O. (2006). Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J. Comp. Neurol. 498, 466-475.

Kant, S., Schumacher, S., Singh, M.K., Kispert, A., Kotlyarov, A, and Gaestel, M. (2006).   Characterization of the atypical MAP kinase ERK4 and its activation of the MAPK-activated protein kinase MK5.  J. Biol. Chem. 281, 35511-35519.

Hinkes, B., Wiggins, R.C., Gbadegesin, R., Vlangos, C.N., Seelow, D., Nurnberg, G., Garg, P., Verma, R., Chaib, H., Hoskins, B.E., Ashraf, S., Becker, C., Hennies, H.C., Goyal, M., Wharram, B.L., Schachter, A.D, Mudumana, S., Drummond, I., Kerjaschki, D., Waldherr, R., Dietrich, A., Ozaltin, F., Bakkaloglu, A., Cleper, R., Basel-Vanagaite, L., Pohl, M., Griebel, M., Tsygin, A.N., Soylu, A., Muller, D., Sorli, C.S., Bunney, T.D., Katan, M., Liu, J., Attanasio, M., O'toole, J.F., Hasselbacher, K., Mucha, B., Otto, E.A., Airik, R., Kispert, A., Kelley, G.G., Smrcka, A.V., Gudermann, T., Holzman, L.B., Nurnberg, P. and  Hildebrandt, F. (2006). Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat. Genet. 38, 1397-1405.


2005

Singh, M.K., Petry, M., Haenig, B., Lescher, B., Leitges, M., Kispert, A. (2005). The T-box transcription factor Tbx15 is required for skeletal development. Mech. Dev. 122, 131-144.

Otto, E.A., Loeys, B., Khanna, H., Hellemans, J., Sudbrak, R., Fan, S., Muerb, U., F. O’Toole, J.F., Helou, J., Attanasio, M., Utsch, B., Sayer, J.A., Lillo, C., Jimeno, D., Coucke, P., De Paepe, A., Reinhardt, R., Klages, S., 5, Tsuda, M., Kawakami, I., Kusakabe, T., Omran, H., Imm, A., Tippens, M., Raymond, P.A., Hill, J., Beales, P., He, S., Kispert, A., Margolis, B., Williams, D.S., Swaroop, A., Hildebrandt, F. (2005). Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Nat. Genet. 37, 282-288.

Horvath, J., Fliegauf, M., Olbrich, H., Kispert, A., King, S.M., Mitchison, H., Zariwala, M.A., Knowles, M.R., Sudbrak, R., Fekete, G., Neesen, J., Reinhardt, R. and Omran, H. (2005). Identification and Analysis of Axonemal Dynein Light Chain 1 in Primary Ciliary Dyskinesia Patients. Am. J. Respir. Cell. Mol. Biol. 33, 41-47.

Singh, M.K., Christoffels, V.M., Dias, J.M., Trowe, M.-O., Petry, M., Schuster-Gossler, K., Bürger, A., Ericson, J. and Kispert, A. (2005). Tbx20 is required for differentiation and formation of cardiac chambers and represses Tbx2. Development 132, 2697-2707.


2004

Hartner, J.C., Schmittwolf, C., Kispert, A., Mueller, A. M., Higuchi, M, and Seeburg, P. H. (2004). Liver Disintegration in the Mouse Embryo by Deficiency in RNA Editing Enzyme ADAR1. J. Biol. Chem. 279, 4894-4902.

Bussen, M., Petry, M., Schuster-Gossler, K., Leitges, M., Gossler, A. and Kispert, A. (2004). The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev. 18, 1209-1222.

Kispert, A. and Gossler, A. (2004). Early mouse development. In: The Laboratory mouse. Ed. by H. Hedrich. Academic Press, San Diego.

Haenig, B., and Kispert, A. (2004). Analysis of TBX18 expression in chick embryos. Development, Genes and Evolution 214, 407-411.p,

Ibañez-Tallon, I., Pagenstecher, A., Fliegauf, M., Olbrich, H., Kispert, A., Ketelsen, U.-P., North, A., Heintz, N., and Omran, H. (2004). Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. Hum. Mol. Genet. 13, 2133-2141.


2003

Kispert, A. and Brändli, A. (2003). Wnts in kidney and genital development. In "Wnt signalling in development", ed. by M. Kühl. Eureka.com (Landes Bioscience).

Kispert, A., Petry, M., Olbrich, H., Volz, A., Ketelsen, U.P., Horvath, J., Melkaoui, R., Omran, H., Zariwala, M., Noone, P.G. and Knowles, M. (2003). Genotype-phenotype correlations in PCD patients carrying DNAH5 mutations. Thorax 58, 552–554.

Majumdar, A., Vainio S., Kispert, A., McMahon, J. and McMahon, A.P. (2003). Wnt-11 and c-Ret/GDNF pathways cooperate in regulating ureteric branching morphogenesis during metanephric kidney development. Development 130, 3175-3185.

Kohlhase, J., Heinrich, M., Liebers, M., Frohlich Archangelo, L., Reardon, W. and Kispert, A. (2003). Cloning and expression analysis of SALL4, the murine homologue of the gene mutated in Okihiro syndrome. Cytogenet. Genome Res. 98, 274-277.

Otto, E.A., Schermer, B., Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Ruf, R.G., Hoefele, J., Beekmann, F., Landau, D., Foreman, J. W., Goodship, J.A.,T Strachan, Kispert, A., Wolf, M.T. Gagnadoux, M.F., Nivet, H., Antignac, C., Walz, G., Drummond, I.A., Benzing,T. and Hildebrandt, F. (2003). Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nature Genetics 34, 413-420.
                        
Olbrich, H., Fliegauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, T. and Omran, H. (2003). Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nature Genetics 34, 455-459.  

Goering, L.M., Hoshijima, K., Hug, B., Bisgrove, B., Kispert, A. and Grunwald, D.J. (2003). An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc. Natl. Acad. Sci. USA 100, 9410-9415.

Moeller, C., Swindell, E.C., Kispert, A. and Eichele, G. (2003). A carboxypeptidase containing a cystein-rich domain regulates the development of the axial skeleton. Development 130, 5103-5111.


2002

Olbrich, H., Häffner, K., Kispert, A., Völkel, A., Volz, A., Sasmaz, G., Lehrach, H., Konietzko, N., Zariwala,  M.,  Knowles, M., Mitchison, H., Chung, E., Hildebrandt, F., Sudbrak, R. and Omran, H. (2002). Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nature Genetics 30,143-144.

Heanue, T.A., Davis, R.J., Rowitch, D.H., Kispert, A., McMahon, A.P., Mardon, G. and Tabin. C.J. (2002). Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech. Dev. 111, 75-87.

Haenig, B., Schmidt, C., Kraus, F., Pfordt, M. and Kispert, A. (2002). Cloning and expression analysis of the chick ortholog of TBX22, the gene mutated in X-linked cleft palate and ankyloglossia. Mech. Dev. 117, 321-325.

Kohlhase, J., Heinrich, M., Schubert, L., Liebers, M., Kispert, A., Laccone, F., Turnpenny, P., Winter, R.M. and Reardon W. (2002). Okihiro syndrome is caused by SALL4 mutations. Hum. Mol. Genet. 11, 2979-2987.


2001

Kuschert, S., Rowitch, D.H., Haenig, B., McMahon, A.P. and Kispert, A. (2001). Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives. Dev. Biology 229, 128-140.

Kraus, F., Haenig, B. and Kispert, A. (2001). Cloning and expression analysis of the mouse T-box gene Tbx18 . Mech. Dev. 100, 83-86.

Kraus, F., Haenig, B. and Kispert, A. (2001). Cloning and expression analysis of the mouse T-box gene Tbx20. Mech. Dev. 100, 87-91.

Bergwitz, C., Wendlandt, T., Kispert, A., von zur Mühlen, A. and Brabant, G. (2001). Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells. Biochim. Biophys. Acta 1538, 129-140.

Buck, A., Kispert, A. and Kohlhase, J (2001). Embryonic expression of the murine homologue of SALL1, the gene mutated in Townes-Brocks syndrome. Mech. Dev.  104, 143-146.

Lickert, H., Kispert, A., Kutsch, R. and Kemler, R. (2001). Expression patterns of Wnt genes in mouse gut development. Mech. Dev. 105, 181-184.

Birkenhäger, R., Otto, E., Schürmann, M.J., Vollmer, M., Ruf, E.-M., Maier-Lutz, I., Beekmann, F., Fekete, A., Konrad, M., Jeck, N., Feldmann, D., Milford, D., Antignac, C., Sudbrak, R., Kispert, A. and Hildebrandt, F. (2001). Bartter syndrome with sensorineural deafness and kidney failure (BSND) is caused by a novel gene expressed in inner ear development.  Nat. Genetics 29, 310-314.

Helmbrecht, K., Kispert, A., von Wasielewski, R. and Brabant, G. (2001). Identification of a Wnt/ß-Catenin signaling pathway in human thyroid cells. Endocrinology 142, 5261-5226.


2000

Lee, C.S., Buttitta, L.A., May, N.R., Kispert, A. and Fan, C.-M. (2000). SHH-N upregulates sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127, 109-118.

Otto, E., Kispert, A., Schätzle, S., Lescher, B., Rensing, C. and Hildebrandt, F. (2000). Nephrocystin: gene expression and sequence conservation between human, mouse, and Caenorhabditis elegans. J. Am. Soc. Nephrol. 11, 270-282.

Arnold, S.J., Stappert, J., Bauer, A., Kispert, A., Herrmann, B.G. and Kemler, R. (2000). Brachyury is a target of the Wnt/-catenin signaling pathway. Mech. Dev. 91, 249-258.

Leitges, M., Neidhardt, L., Haenig, B., Herrmann, B.G. and Kispert, A. (2000). The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Development 127, 2259-2267.


1999

Vainio, S., Heikkila, M., Kispert, A., Chin, N. and McMahon, A.P. (1999). Female development in mammals is regulated by Wnt-4 signalling. Nature 397, 405-409.

Patapoutian, A., Backus, C., Kispert, A. and Reichardt, L.F. (1999). Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors. Science 283, 1180-1183.

Kispert, A., Stoger, R.J., Caparros, M. and Herrmann, B.G. (1999). The mouse rsk3 gene maps to the leh66 elements carrying the t-complex responder Tcr. Mam. Genome 10, 794-802.

Rowitch, D.H., Kispert, A. and McMahon, A.P. (1999). Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum. Brain Res. Dev. Brain Res. 117, 99-108.

Herrmann, B.G., Koschorz, B., Wertz, K., McLoughlin, K.J. and Kispert, A. (1999). A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Nature 402, 141-146.


1998

Kispert, A., Vainio, S. and McMahon, A.P. (1998). Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development 125, 4225-4234.

Lescher, B., Haenig, B. and Kispert, A. (1998). sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev. Dyn. 213, 440-451.


1997

Aberle, H., Bauer, A., Stappert, J., Kispert, A. and Kemler, R. (1997). -catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16, 3797-3804.

Neidhardt, L.M., Kispert, A. and Herrmann, B.G. (1997). A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment, and in the developing vertebral column, kidney and nervous system. Dev. Genes Evol. 207, 330-339.

Pepicelli, C.V., Kispert, A., Rowitch, D.H. and McMahon, A.P. (1997). GDNF induces branching and increased cell proliferation in the ureter of the mouse. Dev. Biol. 192, 193-198.


1996

Kispert, A., Vainio, S., Shen L., Rowitch, D.H. and McMahon, A.P. (1996). Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development 122, 3627-3637.


1995

Kispert, A., Ortner, H., Cooke, J. and Herrmann, B.G. (1995). The chick Brachyury gene: Developmental expression pattern and response to axial induction by localized activin. Dev. Biol. 168, 406-415.

Kispert, A., Koschorz, B. and Herrmann, B.G. (1995). The T protein encoded by Brachyury is a tissue specific transcription factor. EMBO J. 14, 4763-4772.

Hrabe de Angelis, M., Grundker, C., Herrmann, B.G., Kispert, A. and Kirchner, C. (1995). Promotion of gastrulation by maternal growth factor in cultured rabbit blastocystes. Cell Tissue Res. 282 , 147-154.

Kispert, A. (1995). The Brachyury protein: a T-domain transcription factor. Sem. Dev. Biol. 6, 395-403.


1994

Kispert, A. and Herrmann, B.G., (1994). Immunohistochemical analysis of the Brachyury protein in wildtype and mutant mouse embryos. Dev. Biol. 161, 179-193.

Conlon, F.L., Lyons, K.M., Takaesu, N., Barth, K.S., Kispert, A., Herrmann, B.G. and Robertson, E.J. (1994). A primary requirement for nodal in the formation and the maintenance of the primitive streak in the mouse. Development 120, 1919-1928.

Herrmann, B.G. and Kispert, A. (1994). The T genes in embryogenesis. Trends in Genetics 8, 280-286.

Kispert, A., Herrmann, B.G., Leptin, M. and Reuter, R. (1994). Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta. Genes & Dev. 8, 2137-2150.


1993

Stott, D., Kispert, A. and Herrmann, B.G. (1993). Rescue of the tail defect of Brachyury mice. Genes & Dev. 7, 197-203.

Kispert, A. and Herrmann, B.G. (1993). The Brachyury gene encodes a novel DNA-binding protein. EMBO J. 12, 3211-3220, EMBO J. 12, 4898-4899.

Koseki, H., Wallin, J., Wilting, J., Mizutani, Y., Kispert, A., Ebensperger, C., Herrmann, B.G., Christ, B. and Balling, R. (1993). A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae. Development 119, 649-660.


1989

Meyer, D.J., Lalor, E., Coles, B., Kispert, A., Alin, P., Mannervik, B. and Ketterer, B. (1989). Single-step purification and h.p.l.c. analysis of glutathione transferase 8-8 in rat tissues. Biochem. J. 260, 785-788.

Kispert, A., Meyer, D.J., Lalor, E., Coles, B. and Ketterer B. (1989). Purification and characterization of a labile rat glutathione transferase of the Mu class. Biochem. J. 260, 789-793.


PFLEGE-STELLENTICKER

Werden Sie Teil des Pflege-Teams der MHH. Mehr Infos in unserem Stellenticker. Wir freuen uns auf ...

[mehr]

Aktuelle Veranstaltungen

Nierentransplantationskonferenz
18.06.19
17:00 Uhr-18:30 Uhr

TWINCORE Seminar
19.06.19
15:00 Uhr-16:00 Uhr