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Nicht-kanonische zyklische Nukleotide


 

Ausgewählte Publikationen (seit 2013)

 

Bähre H, Kaever V. Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides. Handb Exp Pharmacol 2017; 238:293-306

 

Bähre H, Danker KY, Stasch JP, Kaever V, Seifert R. Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells. Biochem Biophys Res Commun 2014; 443; 1195-1199.

 

Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V, Seifert R. cCMP and cUMP occur in vivo. Biochem Biophys Res Commun 2015; 460: 909-914.

 

Beckert U, Grundmann M, Wolter S, Schwede F, Rehmann H, Kaever V, Kostenis E, Seifert R. cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects. Biochem Biophys Res Commun 2014; 451: 497-502.

 

Beckert U, Wolter S, Hartwig C, Bähre H, Kaever V, Ladant D, Frank DW, Seifert R. ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. Biochem Biophys Res Commun 2014; 450; 870-874. 

 

Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH. cUMP hydrolysis by PDE3A. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 269-280

 

Dittmar F, Abdelilah-Seyfried S, Tschirner SK, Kaever V, Seifert R. Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish. Biochem Biophys Res Commun 2015; 468:708-712

 

Dove S, Danker KY, Stasch JP, Kaever V, Seifert R. Structure/activity Relationships of (M)ANT- and TNP-nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase Alpha1beta1. Mol Pharmacol 2014; 85: 598-607.

 

Hartwig C, Bähre H, Wolter S, Beckert U, Kaever V, Seifert R. cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes. Neurosci Lett 2014; 579C:183-187.

 

Hasan A, Danker KY, Wolter S, Bähre H, Kaever V, Seifert R. Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells. Biochem Biophys Res Commun 2014; 448; 236-240.

 

Kloth C, Schirmer B, Munder A, Stelzer T, Rothschuh J, Seifert R. The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model. Toxins (Basel). 2018;10: pii: E185.

 

 

Laue S, Winterhoff M, Kaever V, van den Heuvel JJ, Russel FG, Seifert R. cCMP is a substrate for MRP5. Naunyn Schmiedebergs Arch Pharmacol 2014; 387: 893-895.

 

Monzel M, Kuhn M, Bähre H, Seifert R, Schneider E. PDE7A1 hydrolyzes cCMP. FEBS Lett 2014; 588: 3469-3474.

 

Morrow KA, Seifert R, Kaever V, Britain AL, Sayner SL, Ochoa CD, Cioffi EA, Frank DW, Rich TC, Stevens T. Heterogeneity of Pulmonary Endothelial Cyclic Nucleotide Response to Pseudomonas aeruginosa ExoY Infection. Am J Physiol Lung Cell Mol Physiol 2015; 309: L1199–L1207

 

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C. The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates. Open Biol 2018; 8: pii: 170250.

 

Ostermeyer J, Golly F, Kaever V, Dove S, Seifert R, Schneider EH. cUMP hydrolysis by PDE3B. Naunyn Schmiedebergs Arch Pharmacol 2018; 391: 891-905

 

Schneider EH, Seifert R. Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.
Handb Exp Pharmacol 2017; 238:169-205

 

Seifert R. cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions. Handb Exp Pharmacol 2017; 238:3-23

 

Seifert R. Distinct Signaling Roles of cIMP, cCMP, and cUMP.  Structure 2016; 24: 1627-1628

 

Seifert R. Recent progress in the field of cIMP research. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 1045-1047.

 

Seifert R. cCMP and cUMP: emerging second messengers. Trends Biochem Sci 2015; 40: 8-15

 

Seifert R, Schneider EH, Bähre H. From canonical to non-canonical cyclic nucleotides as second messengers: Pharmacological implications. Pharmacol Ther 2015; 148C: 154-184

 

Wolter S, Dittmar F, Seifert R. cCMP and cUMP in Apoptosis: Concepts and Methods. Handb Exp Pharmacol 2017; 238: 25-47

 

Wolter S, Dove S, Golombek M, Schwede F, Seifert R. N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo. Naunyn Schmiedebergs Arch Pharmacol 2014; 387: 1163-1175.

 

 

 

 

 

Beiträge des Instituts zum MHH-Forschungsbericht

 

cCMP und cUMP als neue Second Messenger (2014)

 

cCMP-induzierte Apoptose (2015)