Dr. Birgit Weinhold

 

Dr. rer. nat.
Biologin
 

Geb. J3, Ebene 04, Raum 1291 oder 1050
Tel.: +49(0)511/532-8245 oder -9302
FAX: +49(0)511/532-8801
 

E-Mail: Weinhold.Birgit(at)mh-hannover.de
 
 

 

 
Research interests

 
 
- Impact of sialic acids during embryonic development and in the early postnatal phase.
Conditional knock-out and knock-down models targeting the sialic acid activating enzyme CMAS in mice.
 

- The role of polysialic acid in mammals.
Targetet mutagenesis of the polysialic acid transferases St8SiaII and St8SiaIV in mice.
 
 
 

 
Publications

 

Vogt J, Glumm R, Schlüter L, Schmitz D, Rost BR, Streu N, Rister B, Suman Bharathi B, Gagiannis D, Hildebrandt H, Weinhold B, Mühlenhoff M, Naumann T, Savaskan NE, Brauer AU, Reutter W, Heimrich B, Nitsch R, and Horstkorte R. (2012) Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting. Cell Mol Life Sci. 2011 Nov 9.  Epub.

 

Schiff M, Röckle I, Burkhardt H, Weinhold B, and Hildebrandt H. (2011) Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice. J Neurosci.  31(4):1302-12.

 

Galuska SP, Rollenhagen M, Kaup M, Eggers K, Oltmann-Norden I, Schiff M, Hartmann M, Weinhold B, Hildebrandt H, Geyer R, Mühlenhoff M, and Geyer H. (2010) Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc Natl Acad Sci U S A. 107(22):10250-5.

 

Galuska SP, Geyer H, Weinhold B, Kontou M, Röhrich RC, Bernard U, Gerardy-Schahn R, Reutter W, Münster-Kühnel A, and Geyer R. (2010) Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling. Anal Chem. 82(11):4591-8.

 

Pekcec A, Weinhold B, Gerardy-Schahn R, and Potschka H. (2010) Polysialic acid affects pathophysiological consequences of status epilepticus. Neuroreport. 21(8):549-53.

 

Oschlies M, Dickmanns A, Haselhorst T, Schaper W, Stummeyer K, Tiralongo J, Weinhold B, Gerardy-Schahn R, von Itzstein M, Ficner R, and Münster-Kühnel AK. (2009) A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme. J Mol Biol. 393(1):83-97.

 

Schiff M, Weinhold B, Grothe C, and Hildebrandt H. (2009) NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system. J Neurochem. 110(5):1661-73.

 

Drake PM, Stock CM, Nathan JK, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, and Bertozzi CR. (2009) Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc Natl Acad Sci U S A. 106(29):11995-2000.

 

Hildebrandt H, Mühlenhoff M, Oltmann-Norden I, Röckle I, Burkhardt H, Weinhold B, and Gerardy-Schahn R. Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain. 132(Pt 10):2831-8.

 

Mühlenhoff M, Oltmann-Norden I, Weinhold B, Hildebrandt H, and Gerardy-Schahn R. (2009) Brain development needs sugar: the role of polysialic acid in controlling NCAM functions. Biol Chem. 390(7):567-74. Review.  

 

Jungnickel J, Brämer C, Bronzlik P, Lipokatic-Takacs E, Weinhold B, Gerardy-Schahn R, and Grothe C.
(2009) Level and localization of polysialic acid is critical for early peripheral nerve regeneration. Mol Cell Neurosci. 40(3):374-81.  

 

Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy FA 2nd, and Bertozzi CR. (2008) Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol. 181(10):6850-8.  

 

Röckle I, Seidenfaden R, Weinhold B, Mühlenhoff M, Gerardy-Schahn R, and Hildebrandt H. (2008) Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons. Dev Neurobiol. 68(9):1170-84.

 

Potschka H, Pekcec A, Weinhold B, and Gerardy-Schahn R. (2008) Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX. Neuroscience. 152(4):1093-8.

 

Hildebrandt H, Mühlenhoff M, Weinhold B, and Gerardy-Schahn R. (2007) Dissecting polysialic acid and NCAM functions in brain development. J Neurochem. 103 Suppl 1:56-64. Review.

 

Senkov O, Sun M, Weinhold B, Gerardy-Schahn R, Schachner M, and Dityatev A. (2006) Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm. J Neurosci. 26(42):10888-109898.

 

Galuska SP, Oltmann-Norden I, Geyer H, Weinhold B, Kuchelmeister K, Hildebrandt H, Gerardy-Schahn R, Geyer R, and Mühlenhoff M. (2006) Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV. J Biol Chem. 281(42):31605-15.

 

Stoenica L, Senkov O, Gerardy-Schahn R, Weinhold B, Schachner M, and Dityatev A. (2006) In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid. Eur J Neurosci. 23(9):2255-64.

 

Weinhold B, Seidenfaden R, Röckle I, Mühlenhoff M, Schertzinger F, Conzelmann S, Marth JD, Gerardy-Schahn R, and Hildebrandt H. (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem. 280(52):42971-7. 

 

Münster-Kühnel AK, Tiralongo J, Krapp S, Weinhold B, Ritz-Sedlacek V, Jacob U, and Gerardy-Schahn R. (2004) Structure and function of vertebrate CMP-sialic acid synthetases. Glycobiology. 14(10):43R-51R. Review.

 

Münster AK, Weinhold B, Gotza B, Mühlenhoff M, Frosch M, and Gerardy-Schahn R. (2002) Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity. J Biol Chem. 277(22):19688-96.

 

Schratt G, Weinhold B, Lundberg AS, Schuck S, Berger J, Schwarz H, Weinberg RA, Rüther U, and Nordheim A. (2001) Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol Cell Biol. 21(8):2933-43.

 

Weinhold B, Schratt G, Arsenian S, Berger J, Kamino K, Schwarz H, Rüther U, and Nordheim A. (200) Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation. EMBO J. 19(21):5835-44.

 

Arsenian S, Weinhold B, Oelgeschläger M, Rüther U, and Nordheim A. (1998) Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 17(21):6289-99.

 

Weinhold B, and Rüther U. (1997) Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochem J. 327 (Pt 2):425-9.

 

Weinhold B, Bader A, Poli V, and Rüther U. (1997) Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo. Biochem J. 1997 Aug 1;325 (Pt 3):617-21.

 

Eitner F, Westerhuis R, Burg M, Weinhold B, Gröne HJ, Ostendorf T, Rüther U, Koch KM, Rees AJ, and Floege J. (1997) Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo. Kidney Int. 51(1):69-78.