Dr. David Schwarzer
Dr. rer. nat.
Diplom-Biochemiker
Post-Doc
Geb. J3, Ebene 04, Raum 1300 oder 1240
Tel.: +49(0)511/532-8303 oder -9805
FAX: +49(0)511/532-3956
E-Mail: Schwarzer.David(at)mh-hannover.de
Forschungsthemen
- Endosialidasen und weitere tailspike Proteine von Bakteriophagen
Struktur-basierte und enzymologische Charakterisierung
- Kapselpolysaccharide
Synthese, Reinigung and Characterizierung von Kapselpolysacchariden
- Bacteriophagen
Enterobacteriae phage phi92
Evolution von E. coli K1 Bakteriophagen
Veröffentlichungen
Browning, C., Shneider, M., Bowman, V., Schwarzer, D., and Leiman, P. (2012) Phage Pierces the Host Cell Membrane With the Iron-Loaded Spike. Structure 20(2):326-39.
Haastert-Talini, K., Schaper-Rinkel, J., Schmitte, R., Bastian, R., Mühlenhoff, M., Schwarzer, D., Draeger, G., Su, Y., Scheper, T., Gerardy-Schahn, R., and Grothe, C. (2010) In Vivo Evaluation of Polysialic Acid as Part of Tissue-Engineered Nerve Transplants. Tissue Eng. Part A. 16(10):3085–98.
Schulz, E.C., Dickmanns, A., Urlaub, H., Schmitt, A., Mühlenhoff, M., Stummeyer, K., Schwarzer, D., Gerardy-Schahn, R., and Ficner, R. (2010) Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat Struct Mol Biol. 17(2):210–5.
Schulz, E.C., Schwarzer, D., Frank, M., Stummeyer, K., Mühlenhoff, M., Dickmanns, A., Gerardy-Schahn, R., and Ficner, R. (2010) Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF. J Mol Biol. 397(1):341–51.
Schwarzer, D., Stummeyer, K., Haselhorst, T., Freiberger, F., Rode, B., Grove, M., Scheper, T., von Itzstein, M., Mühlenhoff, M., and Gerardy-Schahn, R. (2009) Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F. J. Biol. Chem. 284(14):9465–74.
Berski, S. , van Bergeijk, J., Schwarzer, D., Stark, Y., Kasper, C., Scheper, T., Grothe, C., Gerardy-Schahn, R., Kirschning, A., and Dräger, G. (2008) Synthesis and Biological Evaluation of a Polysialic Acid Based Hydrogel as Enzymatically Degradable Scaffold Material for Tissue Engineering. Biomacromolecules. 9(9):2353–9.
Schwarzer, D., Stummeyer, K., Gerardy-Schahn, R., and Mühlenhoff, M. (2007) Characterization of a novel intra-molecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins. J. Biol. Chem. 282(5):2821–31.
Stummeyer, K., Schwarzer, D., Claus, H., Vogel, U., Gerardy-Schahn, R., Mühlenhoff, M. (2006) Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages. Mol. Microbiol. 60(5):1123–35.
Beiträge zu internationalen Tagungen (Englisch)
Dissertation (März 2004 – Februar 2008)
Characterisation of Bacteriophage-derived Tailspike and Tail Fibre Proteins (link zum PDF auf der Bibliotheksseite (TIB) der Leibniz Universität Hannover)