

Dr. rer. nat.
Diplom-Biologin
Post-Doc
Geb. J3, Ebene 04, Raum 1060
Tel.: +49(0)511/532-3367
FAX: +49(0)511/532-8801
E-Mail: Roeckle.Iris(at)mh-hannover.de
Research interests
Role of polysialic acid and NCAM in interneuron development.
Publications
Schiff M., Röckle I., Burkhardt H., Weinhold B., Hildebrandt H. (2011) Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice. J Neurosci. 31(4):1302-12.
Nacher J., Guirado R., Varea E., Alonso-Llosa G., Röckle I., Hildebrandt H. (2010) Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex. Neuroscience. 167(3):825-37.
Hildebrandt H., Mühlenhoff M., Oltmann-Norden I., Röckle I., Burkhardt H., Weinhold B., Gerardy-Schahn R. (2009) Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain. 132(Pt 10):2831-8.
Röckle I., Seidenfaden R., Weinhold B., Mühlenhoff M., Gerardy-Schahn R., Hildebrandt H. (2008) Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons. Dev Neurobiol. 68(9):1170-84.
Weinhold B., Seidenfaden R., Röckle I., Mühlenhoff M., Schertzinger F., Conzelmann S., Marth J.D., Gerardy-Schahn R., Hildebrandt H. (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem. 280(52):42971-7.