
Wissenschaftliche Mitarbeiterin
Arbeitsschwerpunkte / Aufgaben:
- statistische Beratung
- genetische Epidemiologie
Institut für Biometrie
Medizinische Hochschule Hannover
OE 8410
30625 Hannover
Telefon: (0511) 532 - 65 07
Fax: (0511) 532 - 42 95
E-Mail: Grosshennig.Anika
mh-hannover.de
| seit 03/2009 | Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover | |
| 12/2004 – 02/2009 | Wissenschaftliche Mitarbeiterin in der Medizinischen Klinik II und dem Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck | |
| 10/2000 – 10/2004 | Studium mit Fachrichtung Statistik an der Hochschule Magdeburg-Stendal, Abschluss zur Dipl.-Stat. (FH) | |
| Diplomarbeit: „Statistische Analyse zur Prognose von Krebsmortalitäten - Ein Vergleich von Joinpointregressionen und Bayesianischen Alters-Perioden-Kohortenmodellen“ | ||
Assimes, T. L., Hólm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., Voight, B. F., Erdmann, J., Willenborg, C., Vaidya, D., Xie, C., Patterson, C. C., Morgan, T. M., Burnett, M. S., Li, M., Hlatky, M. A., Knowles, J. W., Thompson, J. R., Absher, D., Iribarren, C., Go, A., Fortmann, S. P., Sidney, S., Risch, N., Tang, H., Myers, R. M., Berger, K., Stoll, M., Shah, S. H., Thorgeirsson, G., Andersen, K., Havulinna, A. S., Herrera, J. E., Faraday, N., Kim, Y., Kral, B. G., Mathias, R. A., Ruczinski, I., Suktitipat, B., Wilson, A. F., Yanek, L. R., Becker, L. C., Linsel-Nitschke, P., Lieb, W., König, I. R., Hengstenberg, C., Fischer, M., Stark, K., Reinhard, W., Winogradow, J., Grassl, M., Großhennig, A., Preuss, M., Schreiber, S., Wichmann, H. E., Meisinger, C., et al. (2010) Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol., 56(19):1552-63
Teupser, D., Baber, R., Ceglarek, U., Scholz, M., Illig, T., Gieger, C., Holdt, L. M., Leichtle, A., Greiser, K. H., Huster, D., Linsel-Nitschke, P., Schäfer, A., Braund, P. S., Tiret, L., Stark, K., Raaz-Schrauder, D., Fiedler, G. M., Wilfert, W., Beutner, F., Gielen, S., Großhennig, A., König, I. R., Lichtner, P., Heid, I. M., Kluttig, A., El Mokhtari, N. E., Rubin, D., Ekici, A. B., Reis, A., Garlichs, C. D., Hall, A. S., et al. (2010) Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet., 3(4):331-9
Ivanyi, P., Winkler, T., Großhennig, A., Reuter, C., Merseburger, A. S., Ganser, A., Grünwald, V. (2010) Treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma is associated with drug-induced hyperparathyroidism: a single center experience in 59 patients. World J Urol., 28(3):311-7
Damm, F., Heuser, M., Morgan, M., Yun, H., Großhennig, A., Göhring, G., Schlegelberger, B., Döhner, K., Ottmann, O., Lübbert, M., Heit, W., Kanz, L., Schlimok, G., Raghavachar, A., Fiedler, W., Kirchner, H., Döhner, H., Heil, G., Ganser, A., Krauter, J. (2010) Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia. J Clin Oncol., 28(4):578-85
Vasan, R. S., Glazer, N. L., Felix, J. F., Lieb, W., Wild, P. S., Felix, S. B., Watzinger, N., Larson, M. G., Smith, N. L., Dehghan, A., Großhennig, A., Schillert, A., Teumer, A., Schmidt, R., Kathiresan, S., Lumley, T., Aulchenko, Y. S., König, I. R., Zeller, T., Homuth, G., Struchalin, M., Aragam, J., Bis, J. C., Rivadeneira, F., Erdmann, J. et al. (2009) Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA, 302(2):168-78.
Erdmann, J., Großhennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Trégouët, D. A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., Voight, B. F., O’Donnell, C. J., Peltonen, L., Siscovick, D. S., Altshuler, D., Merlini, P. A., Peyvandi, F., Bernardinelli, L., Ardissino, D., Schillert, A., et al. (2009) New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet., 41(3):280-2
Trégouët, D. A., König, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Großhennig, A., Linsel-Nitschke, P., Perret, C., Desuremain, M., Meitinger, T., Wright, B. J., Preuss, M., Balmforth, A. J., Ball, S. G., Meisinger, C., Germain, C., Evans, A., Arveiler, D., Luc, G., Ruidavets, J. B., Morrison, C., van der Harst, P., Schreiber, S., Neureuther, K., Schafer, A., Bugert, P., El Mokhtari, N. E., Schrezenmeir, J., et al. (2009) Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet., 41(3):283-5
Myocardial Infarction Genetics Consortium (2009) Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants. Nat. Genet., 41(3):234-41
Coronary Artery Disease Consortium (2009) Large scale association analysis of novel genetic loci for coronary artery disease. ATVB
Linsel-Nitschke, P., Götz, A., Erdmann, J., Braenne, I., Braund, P., Hengstenberg, C., Stark, K., Fischer, M., Schreiber, S., El Mokhtari, N. E., Schaefer, A., Schrezenmeier, J., Rubin, D., Hinney, A., Reinehr, T., Roth, C., Ortlepp, J., Hanrath, P., Hall, A. S., Mangino, M., Lieb,W., Lamina, C., Heid, I. M., Doering, A., Gieger, C., Peters, A., Meitinger, T., Wichmann, H. E., König, I. R., et al. (2008) Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease–a mendelian randomisation study. PLoS ONE, 3(8): e2986.
Samani, N. J., Braund, P. S., Erdmann, J., Götz, A., Tomaszewski, M., Linsel-Nitschke, P., Hajat, C., Mangino, M., Hengstenberg, C., Stark, K., Ziegler, A., Caulfield, M., Burton, P. R., Schunkert, H. & Tobin, M. D. (2008) The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med, 86(11): 1233–41.
Lieb,W., Zeller, T., Mangino, M., Götz, A., Braund, P.,Wenzel, J. J., Horn, C., Proust, C., Linsel-Nitschke, P., Amouyel, P., Bruse, P., Arveiler, D., König, I. R., Ferrieres, J., Ziegler, A., Balmforth, A. J., Evans, A., Ducimetiere, P., Cambien, F., Hengstenberg, C., Stark, K., Hall, A. S., Schunkert, H., Blankenberg, S., Samani, N. J., Erdmann, J. & Tiret, L. (2008) Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. J Mol Med, 86(10): 1163–70.
Schunkert, H., Götz, A., Braund, P., McGinnis, R., Tregouet, D. A., Mangino, M., Linsel-Nitschke, P., Cambien, F., Hengstenberg, C., Stark, K., Blankenberg, S., Tiret, L., Ducimetiere, P., Keniry, A., Ghori, M. J., Schreiber, S., El Mokhtari, N. E., Hall, A. S., Dixon, R. J., Goodall, A. H., Liptau, H., Pollard, H., Schwarz, D. F., Hothorn, L. A., Wichmann, H. E., König, I. R., Fischer, M., Meisinger, C., Ouwehand, W., et al. (2008) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation, 117(13): 1675–84.
Linsel-Nitschke, P., Götz, A., Medack, A., König, I. R., Bruse, P., Lieb, W., Mayer, B., Stark, K., Hengstenberg, C., Fischer, M., Bässler, A., Ziegler, A., Schunkert, H. & Erdmann, J. (2008) Genetic variation in the arachidonate 5-lipoxygenaseactivating protein (ALOX5AP) is associated with myocardial infarction in the german population. Clin Sci (Lond), 115(10): 309–15.
Lieb, W., Mayer, B., König, I. R., Borwitzky, I., Götz, A., Kain, S., Hengstenberg, C., Linsel-Nitschke, P., Fischer, M., Doring, A., Wichmann, H. E., Meitinger, T., Kreutz, R., Ziegler, A., Schunkert, H. & Erdmann, J. (2008) Lack of association between the MEF2A gene and myocardial infarction. Circulation, 117(2): 185–91.
Mayer, B., Lieb, W., Radke, P. W., Götz, A., Fischer, M., Bässler, A., Doehring, L. C., Aherrahrou, Z., Liptau, H., Erdmann, J., Holmer, S., Hense, H.W., Hengstenberg, C. & Schunkert, H. (2007) Association between arterial pressure and coronary artery calcification. J Hypertens, 25(8): 1731–8.
Aherrahrou, Z., Doehring, L. C., Kaczmarek, P. M., Liptau, H., Ehlers, E. M., Pomarino, A.,Wrobel, S., Götz, A., Mayer, B., Erdmann, J. & Schunkert, H. (2007) Ultra-fine mapping of DYSCALC1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Physiol Genomics, 28(2): 203–12.
Mayer, B., Lieb, W., Götz, A., König, I. R., Kauschen, L. F., Linsel-Nitschke, P., Pomarino, A., Holmer, S., Hengstenberg, C., Doering, A., Loewel, H., Hense, H. W., Ziegler, A., Erdmann, J. & Schunkert, H. (2006) Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myo-cardial infarction. J Hypertens, 24(10): 1965–70.
Lieb,W., Graf, J., Götz, A., König, I. R., Mayer, B., Fischer, M., Stritzke, J., Hengstenberg, C., Holmer, S. R., Doring, A., Lowel, H., Schunkert, H. & Erdmann, J. (2006) Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. results of the monica augsburg echocardiographic substudy. J Mol Med, 84(1): 88–96.
Mayer, B., Lieb, W., Götz, A., König, I. R., Aherrahrou, Z., Thiemig, A., Holmer, S., Hengstenberg, C., Doering, A., Loewel, H., Hense, H. W., Schunkert, H. & Erdmann, J. (2005) Association of the T8590C polymorphism of CYP4A11 with hypertension in the monica augsburg echocardiographic substudy. Hypertension, 46(4): 766–71.