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Anika Großhennig

 

Wissenschaftliche Mitarbeiterin

 

 

Arbeitsschwerpunkte / Aufgaben:

 

- statistische Beratung

 

- genetische Epidemiologie

 

 

 

 

Institut für Biometrie

Medizinische Hochschule Hannover

OE 8410

30625 Hannover

Telefon: (0511) 532 - 65 07

Fax: (0511) 532 - 42 95

E-Mail: Grosshennig.Anikamh-hannover.de

 


Werdegang

     
seit 03/2009   Wissenschaftliche Mitarbeiterin am Institut für Biometrie, Medizinische Hochschule Hannover
     
12/2004 – 02/2009   Wissenschaftliche Mitarbeiterin in der Medizinischen Klinik II und dem Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck
     
10/2000 – 10/2004   Studium mit Fachrichtung Statistik an der Hochschule Magdeburg-Stendal, Abschluss zur Dipl.-Stat. (FH)
    Diplomarbeit: „Statistische Analyse zur Prognose von Krebsmortalitäten - Ein Vergleich von Joinpointregressionen und Bayesianischen Alters-Perioden-Kohortenmodellen“
     

Publikationen

 

Assimes, T. L., Hólm, H., Kathiresan, S., Reilly, M. P., Thorleifsson, G., Voight, B. F., Erdmann, J., Willenborg, C., Vaidya, D., Xie, C., Patterson, C. C., Morgan, T. M., Burnett, M. S., Li, M., Hlatky, M. A., Knowles, J. W., Thompson, J. R., Absher, D., Iribarren, C., Go, A., Fortmann, S. P., Sidney, S., Risch, N., Tang, H., Myers, R. M., Berger, K., Stoll, M., Shah, S. H., Thorgeirsson, G., Andersen, K., Havulinna, A. S., Herrera, J. E., Faraday, N., Kim, Y., Kral, B. G., Mathias, R. A., Ruczinski, I., Suktitipat, B., Wilson, A. F., Yanek, L. R., Becker, L. C., Linsel-Nitschke, P., Lieb, W., König, I. R., Hengstenberg, C., Fischer, M., Stark, K., Reinhard, W., Winogradow, J., Grassl, M., Großhennig, A., Preuss, M., Schreiber, S., Wichmann, H. E., Meisinger, C., et al. (2010) Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol., 56(19):1552-63

 

Teupser, D., Baber, R., Ceglarek, U., Scholz, M., Illig, T., Gieger, C., Holdt, L. M., Leichtle, A., Greiser, K. H., Huster, D., Linsel-Nitschke, P., Schäfer, A., Braund, P. S., Tiret, L., Stark, K., Raaz-Schrauder, D., Fiedler, G. M., Wilfert, W., Beutner, F., Gielen, S., Großhennig, A., König, I. R., Lichtner, P., Heid, I. M., Kluttig, A., El Mokhtari, N. E., Rubin, D., Ekici, A. B., Reis, A., Garlichs, C. D., Hall, A. S., et al. (2010) Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet., 3(4):331-9

 

Ivanyi, P., Winkler, T., Großhennig, A., Reuter, C., Merseburger, A. S., Ganser, A., Grünwald, V. (2010) Treatment with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma is associated with drug-induced hyperparathyroidism: a single center experience in 59 patients. World J Urol., 28(3):311-7

 

Damm, F., Heuser, M., Morgan, M., Yun, H., Großhennig, A., Göhring, G., Schlegelberger, B., Döhner, K., Ottmann, O., Lübbert, M., Heit, W., Kanz, L., Schlimok, G., Raghavachar, A., Fiedler, W., Kirchner, H., Döhner, H., Heil, G., Ganser, A., Krauter, J. (2010) Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia. J Clin Oncol., 28(4):578-85

 

Vasan, R. S., Glazer, N. L., Felix, J. F., Lieb, W., Wild, P. S., Felix, S. B., Watzinger, N., Larson, M. G., Smith, N. L., Dehghan, A., Großhennig, A., Schillert, A., Teumer, A., Schmidt, R., Kathiresan, S., Lumley, T., Aulchenko, Y. S., König, I. R., Zeller, T., Homuth, G., Struchalin, M., Aragam, J., Bis, J. C., Rivadeneira, F., Erdmann, J. et al. (2009) Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA, 302(2):168-78.
 

Erdmann, J., Großhennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Trégouët, D. A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., Voight, B. F., O’Donnell, C. J., Peltonen, L., Siscovick, D. S., Altshuler, D., Merlini, P. A., Peyvandi, F., Bernardinelli, L., Ardissino, D., Schillert, A., et al. (2009) New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet., 41(3):280-2

Trégouët, D. A., König, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Großhennig, A., Linsel-Nitschke, P., Perret, C., Desuremain, M., Meitinger, T., Wright, B. J., Preuss, M., Balmforth, A. J., Ball, S. G., Meisinger, C., Germain, C., Evans, A., Arveiler, D., Luc, G., Ruidavets, J. B., Morrison, C., van der Harst, P., Schreiber, S., Neureuther, K., Schafer, A., Bugert, P., El Mokhtari, N. E., Schrezenmeir, J., et al. (2009) Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet., 41(3):283-5

Myocardial Infarction Genetics Consortium (2009) Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants. Nat. Genet., 41(3):234-41

Coronary Artery Disease Consortium (2009) Large scale association analysis of novel genetic loci for coronary artery disease. ATVB

Linsel-Nitschke, P., Götz, A., Erdmann, J., Braenne, I., Braund, P., Hengstenberg, C., Stark, K., Fischer, M., Schreiber, S., El Mokhtari, N. E., Schaefer, A., Schrezenmeier, J., Rubin, D., Hinney, A., Reinehr, T., Roth, C., Ortlepp, J., Hanrath, P., Hall, A. S., Mangino, M., Lieb,W., Lamina, C., Heid, I. M., Doering, A., Gieger, C., Peters, A., Meitinger, T., Wichmann, H. E., König, I. R., et al. (2008) Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease–a mendelian randomisation study. PLoS ONE, 3(8): e2986.

Samani, N. J., Braund, P. S., Erdmann, J., Götz, A., Tomaszewski, M., Linsel-Nitschke, P., Hajat, C., Mangino, M., Hengstenberg, C., Stark, K., Ziegler, A., Caulfield, M., Burton, P. R., Schunkert, H. & Tobin, M. D. (2008) The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med, 86(11): 1233–41.

 

Lieb,W., Zeller, T., Mangino, M., Götz, A., Braund, P.,Wenzel, J. J., Horn, C., Proust, C., Linsel-Nitschke, P., Amouyel, P., Bruse, P., Arveiler, D., König, I. R., Ferrieres, J., Ziegler, A., Balmforth, A. J., Evans, A., Ducimetiere, P., Cambien, F., Hengstenberg, C., Stark, K., Hall, A. S., Schunkert, H., Blankenberg, S., Samani, N. J., Erdmann, J. & Tiret, L. (2008) Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. J Mol Med, 86(10): 1163–70.

Schunkert, H., Götz, A., Braund, P., McGinnis, R., Tregouet, D. A., Mangino, M., Linsel-Nitschke, P., Cambien, F., Hengstenberg, C., Stark, K., Blankenberg, S., Tiret, L., Ducimetiere, P., Keniry, A., Ghori, M. J., Schreiber, S., El Mokhtari, N. E., Hall, A. S., Dixon, R. J., Goodall, A. H., Liptau, H., Pollard, H., Schwarz, D. F., Hothorn, L. A., Wichmann, H. E., König, I. R., Fischer, M., Meisinger, C., Ouwehand, W., et al. (2008) Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation, 117(13): 1675–84.

Linsel-Nitschke, P., Götz, A., Medack, A., König, I. R., Bruse, P., Lieb, W., Mayer, B., Stark, K., Hengstenberg, C., Fischer, M., Bässler, A., Ziegler, A., Schunkert, H. & Erdmann, J. (2008) Genetic variation in the arachidonate  5-lipoxygenaseactivating protein (ALOX5AP) is associated with myocardial infarction in the german population. Clin Sci (Lond), 115(10): 309–15.

Lieb, W., Mayer, B., König, I. R., Borwitzky, I., Götz, A., Kain, S., Hengstenberg, C., Linsel-Nitschke, P., Fischer, M., Doring, A., Wichmann, H. E., Meitinger, T., Kreutz, R., Ziegler, A., Schunkert, H. & Erdmann, J. (2008) Lack of association between the MEF2A gene and myocardial infarction. Circulation, 117(2): 185–91.

Mayer, B., Lieb, W., Radke, P. W., Götz, A., Fischer, M., Bässler, A., Doehring, L. C., Aherrahrou, Z., Liptau, H., Erdmann, J., Holmer, S., Hense, H.W., Hengstenberg, C. & Schunkert, H. (2007) Association between arterial pressure and coronary artery calcification. J Hypertens, 25(8): 1731–8.

Aherrahrou, Z., Doehring, L. C., Kaczmarek, P. M., Liptau, H., Ehlers, E. M., Pomarino, A.,Wrobel, S., Götz, A., Mayer, B., Erdmann, J. & Schunkert, H. (2007) Ultra-fine mapping of DYSCALC1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Physiol Genomics, 28(2): 203–12.

Mayer, B., Lieb, W., Götz, A., König, I. R., Kauschen, L. F., Linsel-Nitschke, P., Pomarino, A., Holmer, S., Hengstenberg, C., Doering, A., Loewel, H., Hense, H. W., Ziegler, A., Erdmann, J. & Schunkert, H. (2006) Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myo-cardial infarction. J Hypertens, 24(10): 1965–70.

Lieb,W., Graf, J., Götz, A., König, I. R., Mayer, B., Fischer, M., Stritzke, J., Hengstenberg, C., Holmer, S. R., Doring, A., Lowel, H., Schunkert, H. & Erdmann, J. (2006) Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. results of the monica augsburg echocardiographic substudy. J Mol Med, 84(1): 88–96.

Mayer, B., Lieb, W., Götz, A., König, I. R., Aherrahrou, Z., Thiemig, A., Holmer, S., Hengstenberg, C., Doering, A., Loewel, H., Hense, H. W., Schunkert, H. & Erdmann, J. (2005) Association of the T8590C polymorphism of CYP4A11 with hypertension in the monica augsburg echocardiographic substudy. Hypertension, 46(4): 766–71.