Medizinische Hochschule Hannover | Carl-Neuberg-Str.1 | 30625 Hannover | Tel.:(+49) 0511-532-0

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Institute of Experimental Hematology at MHH

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The Institute of Experimental Hematology investigates the biology of blood cell formation and function with a special focus on genetic cell modification as a new therapeutic modality.

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	Our research groups collaborate to form a portfolio ranging from the generation and expansion of stem cells to the control or enhancement of cell differentiation and function. We connect basic research and strong translational efforts in the field of molecular cell modification for the treatment of severe blood diseases, such as immune disorders and leukemia. The detection and prevention of risks associated with genetic cell modification and training of young scientists are important missions of our Institute.
The Institute of Experimental Hematology contributes to strong research networks of Hannover Medical School, including the DFG-funded cluster of excellence REBIRTH http://www.rebirth-hannover.de/, the collaborative research center SFB738 http://www.sfb738.de/start.html, and the Integrated Research and Treatment Center for Transplantation Medicine (IFB-Tx) http://www.ifb-tx.de/. Furthermore, we participate in the DFG-funded research priority program “mechanisms of gene vector entry and persistence” (SPP1230) http://www.schwerpunktprogramm1230.de/, several network projects supported by the BMBF http://www.bmbf.de/de/1398.php and the DAAD http://www.daad.de/de/index.html and integrated projects of the EU (PERSIST http://www.persist-project.eu/, CELL-PID http://dev.cell-pid.eu/index.pl).
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The director of the Institute of Experimental Hematology is Prof. Dr. med. Christopher Baum, who also serves as Dean of Research of Hannover Medical School since 2007. Group leaders are Toni Cathomen, Jürgen Bode, Ute Modlich, Axel Schambach, Bernhard Schiedlmeier, Zhixiong Li, Johann Meyer und Christopher Baum.
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Head of Institute

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Professor Dr. Christopher Baum Hannover Medical School Experimental Hematology OE 6960 Carl-Neuberg-Str. 1 D-30625 Hannover Germany
E-Mail: Baum.Christopher[at]mh-hannover.de Fon: +49 511 532 6067 Fax: +49 511 532 6068
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Scientific goals

The unifying topic of our research is induced and pathologic regeneration of blood cell formation (hematopoiesis). Our scientific goals are

the analysis of the mechanisms underlying differentiation of pluripotent cells to hematopoietic stem cells

the discovery of novel pathways that support self-renewal and competitive fitness of normal and malignant hematopoietic stem cells

the development of novel cell and gene therapeutics for inherited or acquired disorders, based on molecular insights into mechanisms of vector-host interactions.

the implementation of rational genome engineering strategies in somatic stem cells to characterize and treat inherited or acquired disorders of the hematopoietic system, based on molecular insights into the cellular DNA repair machinery and the processes that govern the differentiation and de-differentiation between committed somatic cells and pluripotent stem cells.

We attempt to combine biological and technological progress with a detailed risk assessment of novel therapeutic approaches. Our scope ranges from basic mechanisms of genetic cell modification to translational projects that establish improved conditions for clinical trials using advanced therapy medicinal products.

Research at the Institute of Experimental Hematology

Mechanisms underlying insertional transformation of hematopoietic stem cells

Principal Investigator Christopher Baum

Chromosome-based vectors

Principal Investigator Jürgen Bode

Targeted Genome Engineering

Principal Investigator Toni Cathomen

Leukemogenesis and molecular therapy

Principal Investigator Zhixiong Li

Receptor Biology and Signal transduction

Principal Investigator Johann Meyer

Biosafety of gene therapy