Publications
| |
The fate of rAAV vector genomes during DNA double strand break induced gene targeting in human cells. Hum Gene Ther. 2010 May;21(5):543-53. | |
| |
Zinc-finger Nuclease-induced Gene Repair With Oligodeoxynucleotides: Wanted and Unwanted Target Locus Modifications. Mol Ther. 2010 Apr;18(4):743-53. Epub 2010 Jan 12. | |
| |
Zinc-finger nucleases meet iPS cells: Zinc positive: tailored genome engineering meets reprogramming.Gene Ther. 2010 Jan;17(1):1-3. Epub 2009 Nov 12. | |
| |
Reply to "Genome editing with modularly assembled zinc-finger nucleases" (Commentary). Nat Meth 7: 91-92. | |
| |
Impaired axonal transport in motor neurons correlates with clinical prion disease. PLoS Pathog. 2009 August; 5(8): e1000558. | |
| |
Ultramicroscopy reveals axonal transport impairments in cortical motor neurons at prion disease. Biophys J. 2009 Apr 22;96(8):3390-8. | |
Händel E.-M., Alwin, S., and Cathomen T. (2009) |
|
Expanding or restricting the target site repertoire of zinc-finger nucleases: The inter-domain linker as a major determinant of target site selectivity. Mol Ther 17, 104-111.
|
Maeder M.L., Thibodeau-Beganny S., Osiak A., Wright D.A., Anthony R.M., Eichtinger M., Jiang T., Foley J.E., Winfrey R.J., Townsend J.A., Unger-Wallace E., Sander J.D., Müller-Lerch F., Fu F., Pearlberg J., Göbel C., Dassie J.P., Pruett-Miller S.M., Porteus M.H., Sgroi D.C., Iafrate A.J., Dobbs D., McCray P.B. Jr., Cathomen T., Voytas D.F., and Joung J.K. (2008) |
|
Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell 31, 294-301.
|
Cathomen T. and Joung J.K. (2008) |
|
Zinc-finger nucleases: The next generation emerges (Invited Review). Mol Ther 16, 1200-1207.
|
Bohne J. and Cathomen T. (2008) |
|
Genotoxicity in gene therapy: An account of vector integration and designer nucleases (Invited Review). Curr Opin Mol Ther 10, 214-223.
Cathomen T., Segal D.J., Brondani V., and Müller-Lerch F. (2008) |
|
Generation and functional analysis of zinc-finger nucleases (Invited Book Chapter). Methods Mol Biol 434, 277-290.
|
Ramirez C.L., Foley J.E., Wright D.A., Müller-Lerch F., Rahman S.H., Cornu T.I., Winfrey R.J., Sander J.D., Fu F., Townsend J.A., Cathomen T., Voytas D.F., and Joung J.K. (2008) |
|
Unexpected failure rates for modular assembly of engineered zinc fingers. Nat Methods 5, 374-375.
|
Cornu T.I., Thibodeau-Beganny S., Guhl E., Alwin S., Eichtinger M., Joung J.K., and Cathomen T. (2008) |
|
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol Ther 16, 352-358.
|
Cornu T.I. and Cathomen T. (2007) |
|
Targeted genome modifications using integrase-deficient lentiviral vectors. Mol Ther 15, 2107-2113.
|
Szczepek M., Brondani V., Büchel J., Serrano L., Segal D.J., and Cathomen T. (2007) |
|
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol 25, 786-793.
|
Radecke F., Peter I., Radecke S., Gellhaus K., Schwarz K., and Cathomen T. (2006) |
|
Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break. Mol Ther 14, 798-808.
|
Cathomen T. (2006) |
|
rAAV vectors for gene targeting (Invited Book Chapter). In Parvoviruses (Kerr J.R., Cotmore, S.F., Bloom, M.E., Linden R.M., and Parish, C.R., Eds.), pp. 543-549. Hodder Arnold, London, UK.
Alwin S., Gere M.B., Guhl E., Effertz K., Barbas C.F. III., Segal D.J., Weitzman M.D., and Cathomen T. (2005) |
|
Custom zinc-finger nucleases for use in human cells. Mol Ther 12, 610-617.
|
Cathomen T. (2004) |
|
AAV vectors for gene targeting (Review). Curr Opin Mol Ther 6, 360-366.
Porteus M.H., Cathomen T., Weitzman M.D. and Baltimore D. (2003) |
|
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol 23, 3558-3565.
|
Weitzman MD, Young SM Jr, Cathomen T, Samulski RJ. (2003) |
|
Targeted integration by adeno-associated virus.Methods Mol Med. 2003;76:201-19.
Blutkonserven sind an der MHH häufig knapp. Warum?
Die Medizinische Hochschule Hannover hat sich zur größten Transplantationsklinik in Deutschland entw...