StartseiteSitemapImpressumdeutschenglish
MHH Logo

Gruppenmitglied - Anurag Kumar Singh, MSc, PhD

Curriculum Vitae

Studium:

1999 - 2002

BSc. Hons. Chemistry Banaras Hindu University, India

2002 - 2004

MSc. Biotechnology Madurai Kamaraj University, India

2004 - 2008

PhD (MD/PhD program "Molecular Medicine"), Medizinische Hochschule Hannover

Doktorarbeit:

"Duodenal mucusal bicarbonate secretion: role of CFTR, Slc26a6, carbonic anhydrase (II) and NHERF family adapter proteins in health and disease”, Hannover 2008, (excellent)

Beruflicher Werdegang

seit Juni 2008

Promovierter wissenschaftlicher Mitarbeiter, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover

10/2004 - 06/2008

Doktorarbeit, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover

PhD Doktorarbeit bei Prof. Dr. med. Ursula Seidler

07/2003 - 06/2004

MSc-Projekt unter Betreuung von Dr. Aditya K. Gupta, School of Biotechnology, Madurai Kamaraj University, Madurai

Thema:

"Cloning of putative pectin methyl esterase from Indica rice into plant expression vector in sense and antisense direction"

05/2003 - 07/2003

Sommerpraktikum unter Betreuung von Dr. Anita Damodaran, Unilever, Bangalore

Thema:

"Development of methodology to derivatize melatonin and quantification of derivatized product"

Preise, Leistungen & Stipendien

  • Young Investigators Travel Grant for the 36th Congress of the Internal Union of Physiological Sciences (IUPS2009).
  • Young Physiologists Bursary Scheme (YPBS) travel award of The Physiological Society 2008 Main Meeting (Cambridge), 14-16 July, 2008
  • Novartis Young Fellows Travel Award for 5th European Cystic Fibrosis Society New Frontiers in Basic Science of Cystic Fibrosis, Douro, Portugal, 9-13 April, 2008.
  • Posterpreis 5th European Cystic Fibrosis Society New Frontiers in Basic Science of Cystic Fibrosis, Douro, Portugal, 9-13 April, 2008.
  • Novartis Young Fellows Travel Award for the 5th European Cystic Fibrosis Society New Frontiers in Basic Science of Cystic Fibrosis, Tavira, Algarve, Portugal, 25-29 April, 2007.
  • Stipendium der "Gesellschaft der Freunde der MHH", Medizinische Hochschule Hannover 2004 - 2008.
  • Zweijähriges Forschungsstipendium (2002-2004) der indischen Regierung für den MSc-Biotechnologiekurs bei MKU, Department of Biotechnology.
  • Qualifizierung für GATE (Graduate Aptitude Test for Engineering) 2004, Erreichung eines Perzentilwerts von 99,14. Gesamtindischer Platz 40.
  • CSIR JRF Dezember 2003.
  • Siebenjähriges Stipendium (1991 - 1998) des indischen Arbeitsministeriums zur Sekundär- und Hochschulausbildung bei Jawahar Navodaya Vidyalaya.

Publikationen:

 

  1. Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest. 2009 Mar;119(3):540-50. doi: 10.1172/JCI35541. Epub 2009 Feb 16.
  2. Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Siedler U, Zuo J, Soleimani M. Slc2a5 (Glut) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension. J Biol Chem. 2009 Feb 20;284(8):5056-66. Epup 2008 Dec 17.
  3. Seidler U, Singh A, Chen M, Cinar A, Bachmann O, Zheng W, Wang J, Yeruva S, Riederer B. Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insight into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension. Exp Physiol. 2009 Feb;94(2):175-9. Epup 2008 Oct 17.
  4. Zheng W, Kuhlicke J, Jäckel K, Eltzschig HK, Singh A, Sjöblom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J. Hypoxia inducibl factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J. 2008 Sep 8.
  5. Broere N, Chen M, Cinar A, Singh AK, Hillesheim J, Riederer B, Lünnemann M, Rottinghaus I, Krabbenhöft A, Engelhardt R, Rausch B, Weinman EJ, Donowitz M, Hubbard A, Kocher O, de Jonge HR, Hogema BM, Seidler U. Defective jejunal and colonic salt absorption and altered Na(+)/H(+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflugers Arch. 2008 Aug 29.
  6. Sander LE, Obermeier F, Dierssen U, Kroy DC, Singh AK, Seidler U, Streetz KL, Lutz HH, Müller W, Tacke F, Trautwein C. Gp130 signaling promotes developement of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation. J Immunol. 2008 Sep 1;181(5):3586-94.
  7. Singh AK, Amlal H, Haas PJ, Dringenberg U, Fussel S, Barone SL, Engelhardt R, Zuo J, Seidler U, Soleimani M. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008 Aug;74(4):438-47. Ebup 2008 May 21.
  8. Singh AK, Sjöblom M, Zheng W, Krabbenhöft A, Riederer B, Rausch B, Manns MP, Soleimani M, Seidler U. CFTR and its key role in vivo resting and luminal acid-induced duodenal HCO3-secretion. Acta Physiol (Oxf). 2008 Aug;193(4):357-65. Epub 2008 Mar 21.
  9. Ukena SN, Singh A, Dringenberg U, Engelhardt R, Seidler U, Hansen W, Bleich A, Bruder D, Franzke A, Rogler G, Suerbaum S, Buer J, Gunzer F, Westendorf AM. Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS ONE. 2007 Dec 12;2(12):e1308.