Projects
A 2.2.a) Exploitation of intact immune functions for Salmonella infections and dissemination
Project Leaders: Reinhold Förster/Oliver Pabst
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A 2.2.b) Spatiotemporal dynamics of acute and chronic Salmonella infection in mice
Project Leader: Oliver Pabst
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A 2.3 Molecular and genetic factors determining persistent Salmonella infection
Project Leader: Mikael Rhen
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A 2.4.a) Role of msrA and tpx in resistance of Mycobacterium tuberculosis and Salmonella enterica serovar Typhimurium to oxidative and nitrosative stress
Project Leader: Franz Christoph Bange
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A 2.4.b) Molecular mechanisms of resistance to oxidative and nitrosative stress in Mycobacterium tuberculosis and Salmonella typhimurium: characterization of the mutant x and the thioredoxins B and C
Project Leader: Franz Christoph Bange
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A 2.5 Helicobacter pylori persistence in the gastric ecosystem and its impact on gastroduodenal disease
Project Leader: Lars Engstrand
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A 2.6.a) Role of the LANA-1 protein of Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) in latent persistency by controlling the turnover of associated nuclear proteins
Project Leader: Thomas F. Schulz
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A 2.6.b) The role of Brd2 and other cellular nuclear kinases in LANA-1 and EBNA-1 mediated episomal replicaton and latency
Project Leader: Thomas F. Schulz
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A 2.7 Viral oncogenesis - modulation of the ubiquitin-proteasome system in virus infected cells
Project Leader: Maria G. Masucci
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A 2.8.b) Mechanisms generating allelic diversity during chronic infection
Project Leader: Sebastian Suerbaum
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A 2.9 Molecular mechanisms of Helicobacter pylori cell surface diversity to avoid immune recognition
Project Leader: Staffan Normark
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A 2.10 Helicobacter pylori strain specificities and risk of stomach cancer
Project Leader: Olof Nyrén
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A 2.11 Variability of the Plasmodium falciparum genome during chronic infection
Project Leader: Mats Wahlgren
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A 2.12 Biofilm formation of Pseudomonas aeruginosa in a model medium for chronic lung infection
Project Leader: Ute Römling
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A 2.13.a) Intercellular communication in Pseudomonas aeruginosa
Project Leaders: Susanne Häussler/Jürgen Wehland
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A 2.13.b) Impact of environmental and bacterial signals on the establishment and recalcitrance of Pseudomonas aeruginosa biofilms
Project Leader: Susanne Häussler
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A 2.15 Molecular mechanisms of host susceptibility to invasive pneumococcal disease
Project Leader: Birgitta Henriques Normark
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A 2.16 Functional characterization of pathogen-induced regulatory T cells in chronic inflammation
Project Leader: Jan Buer, Dunja Bruder/Robert Geffers/Jürgen Wehland
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A 2.17.a) Immunomodulatory effects of Helicobacter infection and gastrointestinal colonization by other bacteria: the role of TRAF6 and ubiquitylation
Project Leader: Christine Josenhans
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A 2.17.b) Characterization of mechanisms mediating energy taxis of Helicobacter species
Project Leader: Christine Josenhans
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A 2.18.a) The role of TRAIL in interferon alpha-mediated clearance of HCV in patients with acute and chronic hepatitis C
Project Leaders: Heiner Wedemeyer/Michael Manns
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A 2.18.b) Effects of type I interferons on human NK cells: Relevance for hepatitis C virus infection
Project Leader: Heiner Wedemeyer
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A 2.19.a) Characterization of immune cells from HCV infected patients to improve vaccine design
Project Leader: Carlos A Guzmán
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A 2.19.b) Identification of immune modulators acting on NK and NKT cells which affect hepatocytes infection by the HCV virus
Project Leader: Carlos A Guzmán
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A 2.20.a) Effector-protein dependent signaling pathways and host responses in chlamydial persistence
Project Leader: Andreas Klos
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A 2.20.b) Chlamydial virulence factors related to the complement system and culture conditions
Project Leader: Andreas Klos
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A 2.21 Role and regulation of IFN-γ in control of infection with Chlamydia pneumoniae
Project Leader: Martin Rottenberg
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A 2.22.a) Analysis of signal transduction events induced by pathogenic bacteria upon interaction with host cells: Comparative phosphoproteome analyses of the infected host cell
Project Leaders: Lothar Jänsch/Jürgen Wehland
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A 2.22.b) Molecular mechanisms of NK cell cytotoxicity: Analysis of activated receptor signaling
Project Leader: Lothar Jänsch
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A 2.23 Structural studies of mechanisms underlying viral escape from T cell mediated immunity
Project Leaders: Hans-Gustaf Ljunggren/Adnane Achour
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A 2.24 Analysis of the mechanisms underlying the lethal synergism between viral and bacterial infections - role of Toll like receptors (TLR), especially TLR7
Project Leaders: Matthias Gunzer/Jürgen Wehland
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A 2.25 Kinetics and quality of antigen-presenting cells-T cell contact during HIV infection
Project Leader: Francesca Chiodi
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A 2.26.b) Pattern molecule synthesis during colonization and infection
Project Leader: Mathias Hornef
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A 2.27.a) Analysis of the role of the hepatitis c virus hyper variable region for virus uptake and infection
Project Leader: Thomas Pietschmann
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A 2.27.b) In vivo and in vitro correlates of hepatitis C virus replication
Project Leader: Thomas Pietschmann
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A 2.28 Role of GPR15 in HIV and SIV cell tropism and apoptosis induction
Project Leader: Stefan Pöhlmann
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A 2.29 Environmental control of virulence by members of the SlyA/RovA regular family
Project Leader: Petra Dersch
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A 2.31 Determinants of host specificity of Campylobacter species in colonisation and disease
Project Leader: Christine Josenhans
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