SPRD-Cu3

Genotype:

Pigmentation genes:aa BB cc hh PP RR

Mhc: RT1^lv3(RT1.A^lB/D^lC^lv3)

Erythrocyte antigens: RT2 ^b RT3 ^b RT8 ^b

Lymphocyte antigens: RT6 ^b RT7 ^b

Inbr. Gen.: At Ztm (1998), F51.

Origin: From outbred Han:SPRD (Sprague-Dawley) rats. Dominant pelage mutation designated curly-3 (Cu3) occurred in 1975 at Gesellschaft für Strahlenforschung, Dortmund, FRG. Mutant animals returned to Han, where inbreeding began in 1976, to Ztm in 1994.

Reproduction: Good reproductive performance; average number weaned per female per week 1.1.

Characteristics: Highly susceptible to induction of mammary tumors by oral application of 7, 12 dimethylbenz[a]anthracene (DMBA) to 50-55 days old female rats. Major histocompatibility complex described by Hedrich et al. (2). Genetic marker profile described by Bender et al. (1994) (1).

References:

Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H. J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.

Hedrich, H. J., K. Wonigeit, and E. Günther. 1983. Description of a new RT11 variant and mapping of the variant gene to the RT1.C region. Transplant. Proc. 15: 1562–1564.