E3

Genotype:

Pigmentation genes: aa BB CC hh PP rr

Mhc: RT1^u(RT1.A^uB/D^uC^u)

Erythrocyte antigens: RT2 ^a RT8 ^b

Lymphocyte antigens: RT6 ^b RT7 ^a

Inbr. Gen.: At Ztm (1998), F103.

Origin: Kn, Göttingen, in 1949 from rats of unknown origin, with selection of brother-sister pairs for the red-eyed, yellow, black-hooded genotype. To Han in 1957 at F16. To Gottschewski in 1964, back to Han in 1968, to Ztm 1994.

Reproduction: Moderate reproductive performance; average number weaned per female per week 0.69.

Characteristics: Concordant with the pigmentation defect (red-eyed dilution) exhibits a platelet storage pool disease. Animals develop a mild from of hemorrhagic diathesis, which increases with age and injuries.The genetic maker profile described by Bender et al. (1).

References:

1. Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H. J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.