DA

Genotype:

Pigmention genes: AA BB CC HH PP RR

Mhc: RT1 ^av1(RT1.A^aB/D^aC^av1)

Erythrocyte antigenes: RT2 ^b RT8 ^b

Lymphocyte antigenes: RT6 ^b RT7 ^a

Inbr. Gen.: At Ztm (1998), F96.

Origin: Inbred from heterogeneous stocks with unknown antecedents. 376 suggest that it may be related to COP. From Wistar Institute to Oxf in 1963 (Williams, pers. comm). To Han in 1972, to Ztm 1994.

Reproduction: Moderate reproductive performance with 0,53 young/female/litter.

Tumours (Spontaneous): Incidence of urinary bladder tumours 54% in male and 14% in female DA/Han rats. Peak incidence between 25 and 30 months of age (2).

Other Characteristics: Susceptible to induction of autoimmune thyroiditis (11). Defective bile acid transport found in females; might serve as a model for debrisoquine hydroxylation deficiency in man (10). Glomerular filtration rate (gfr) and renal plasma flow (rpf) compared in several inbred strains. DA rats are highly susceptible to induction of chronic and acute arthritis by rat collagen II an incomplete adjuvant, with differential patterns and T cell involvement (6, 7, 9). Gfr of DA/Ztm, 2.26 ml/min; rpf, 5.26 ml/min (4). Hematological parameters and their relation to diet described by Hackbarth et al. (6) for DA/Ztm and several other inbred strains. The major histocompatibility complex has been described (3, 7, 12), the genetic maker profile described by Bender et al. (1).

References:

1. Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H. J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.

2. Deerberg, F., S. Rehm, and H. H. Jostmeyer. 1985. Spontaneous urinary bladder tumors in DA/Han rats: A feasible model of human bladder cancer. J. Natl. Cancer Inst. 75: 1113 1121.

3. Günther, E., E. Rüde, and O. Stark. 1972. Antibody response in rats to the synthetic polypeptide (T,G)-A--L genetically linked to the major histocompatibility system. Eur. J. Immunol. 2: 151 155.

4. Hackbarth, H., E. Baunack, and M. Winn. 1981. Strain differences in kidney function of inbred rats: 1. Glomerular filtration rate and renal plasma flow. Lab. Anim. (London) 15: 125 128.

5. Hackbarth, H., K. Burow, and G. Schimansky. 1983. Strain differences in inbred rats: Influence of strain and diet on haematological traits. Lab. Anim. (London) 17: 7 12.

6. Holmdahl, R., T.J. Goldschmidt, S. Kleinau, C. Kvick und R. Jonsson. 1992. Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease. Immunology. 76: 197-202.

7. Holmdahl,R. und C. Kvick. 1992. Vaccination and genetic experiments demonstrate that adjuvant-oil-induced arthritis and homologous type II collagen-induced arthritis in the same rat strain are different diseases. Clin-Exp-Immunol. 88: 96-100.

8. Kunz, H. W., T. J. Gill III, and B. Borland. 1974. The genetic linkage of the immune response of poly(Glu52Lys33Tyr15) to the major histocompatibility locus in inbred rats. J. Immunogenet. 1: 277 287.

9. Persson, S., C. Post, R. Holmdah und F. Nyberg.1992. Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats. Brain-Res. 581: 273-82.

10. Reichen, J., S. Krahenbuhl, A. Kupfer, H. Sagresser, and G. Karlaganis. 1986. Defective bile acid transport in an animal model of defective debrisoquine hydroxylation. Biochem. Pharmacol. 35: 753 759.

11. Rose, N. R. 1975. Differing responses of inbred rat strains in experimental autoimmune thyroiditis. Cell. Immunol. 18: 360 364.

12. Stark, O., V. Kren, B. Frenzl, and D. Krenova. 1968. Histocompatibility-1 alleles in inbred rats of the BD II, WR, AGA, CDF, AS, BS, HS and DA strains. Folia Biol. (Prague) 14: 425 432.