BS

Genotype:

Pigmentation genes: aa BB CC HH PP RR

Mhc: RT1^l(RT1.A^lB/D^lC^l)

Erythrocyte antigens: RT2 ^b RT3 ^b

Lymphocyte antigens: RT6 ^b RT7 ^a

Inbr. Gen.: At Ztm (1998), F35.

Origin: University of Otago Medical School from a cross between wild rats and outbred Wistar rats, with the F1 hybrids backcrossed to Wistar stock (4).

Reproduction: Poor reproductive performance; average number born per litter 6.04, average number weaned per litter 1.9. Neonates tend to die in first 2-3 days, even if they are fostered (Heslop, pers. comm.).

Behavioural Characteristic: Docile.

Other Characteristic: Major histocompatibility complex described by Stark et al. (3) and Günther et al. (2), genetic marker profile described by Bender et al. (1)

References:

1. Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H.J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.

2. Günther, E., E. Rüde, and O. Stark. 1972. Antibody response in rats to the synthetic polypeptide (T,G)-A--L genetically linked to the major histocompatibility system. Eur. J. Immunol. 2: 151 155.

3. Stark, O., V. Kren, B. Frenzl, and D. Krenova. 1968. Histocompatibility-1 alleles in inbred rats of the BD II, WR, AGA, CDF, AS, BS, HS and DA strains. Folia Biol. (Prague) 14: 425 432.

4. Zeiss, I. M. 1966. Demonstration of isohistogenicity in groups of rats from partially inbred strains. Transplantation 4: 506 509.