BH

Colour: Black-hooded (a, B, C, h).

Genotype:

Pigmentation genes: aa BB CC hh Mhc: RT1^l(RT1.A^lB/D^lC^l) Erythrocyte antigens: RT2 ^a RT3 ^b RT8 ^b Lymphocyte antigens: RT6 ^b RT7 ^b

Inbr. Gen.: At Ztm (1998), F38.

Origin: D. Wilson, University of Pennsylvania, from unknown stock. To Dml, who transferred animals to University of Iowa in 1973.

Reproduction: At Ztm, good reproductive performance; average litter size 7.0±3.2. Interval between litters 37.4 ± 19 days with peaks between 23 and 33 days and at 58 days.

Characteristics: Used with LEW and congenic strains to define alloantigenic systems RT6 and RT7 (3, 8, 9, 10). Not susceptible to induction of experimental allergic encephalomyelitis (4,7; Wonigeit pers. comm.). This nonsusceptibility appears to be controlled by genes not linked to the major histocompatibility complex (RT1) (4, 11). Glomerular filtration rate (gfr) and renal plasma flow (rpf) compared in several inbred strains. Gfr of BH/Ztm, 2.44 ml/min; rpf, 3.55 ml/min (5). Hematologic parameters and their relation to diet described by Hackbarth et al. (6) in BH/Ztm and several other strains. Biochemical genetic marker profile described by Bender et al. (1, 2).

References:

1. Bender, K., M. Adams, P. R. Baverstock, M. den Bieman, S. Bissbort, R. Brdicka, G. W. Butcher, D. V. Cramer, O. von Deimling, M. F. W. Festing, E. Günther, R. D. Guttmann, H. J. Hedrich, P. B. Kendall, R. Kluge, R. Moutier, B. Simon, J. E. Womack, J. Yamada, and B. van Zutphen. 1984. Biochemical markers in inbred strains of the rat (Rattus norvegicus). Immunogenetics 19: 257 266.

2. Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H. J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.

3. Ely, J. M., D. L. Greiner, D. M. Lubaroff, and F. W. Fitch. 1983. Characterization of monoclonal antibodies that define rat T cell alloantigens. J. Immunol. 130: 2798 2803.

4. Gasser, D. L., S. J. Baloyannis, and N. K. Gonatas. 1978. Influence of MHC-linked and non-MHC-linked genes on susceptibility of rats to experimental allergic encephalomyelitits. In N. R. Rose, P. E. Bigazzi, and N. L. Warner, eds., Genetic Control of Autoimmune Disease, 355 364, Elsevier-North Holland, New York.

5. Hackbarth, H., E. Baunack, and M. Winn. 1981. Strain differences in kidney function of inbred rats: 1. Glomerular filtration rate and renal plasma flow. Lab. Anim. (London) 15: 125 128.

6. Hackbarth, H., K. Burow, and G. Schimansky. 1983. Strain differences in inbred rats: Influence of strain and diet on haematological traits. Lab. Anim. (London) 17: 7 12.

7. Herzog, S., K. Wonigeit, K. Freese, H. J. Hedrich, and R. Rott. 1985. Effect of Borna disease virus infection on athymic nude rats. Gen. Virol. 66: 503 508.

8. Lubaroff, D. M., G. T. Rasmussen, and H. D. Hunt. 1979. Comparative studies of T-lymphocyte antigens in the rat: Are ART, Ly, Pta, and Ag-F the same? Transplant. Proc. 11. 1642 1645.

9. Lubaroff, D. M., H. D. Hunt, and G. T. Rasmussen. 1985. Evidence from capping experiments for independence of the RT7 alloantigen and the leucocyte common antigen in the rat. J. Immunogenet. 12: 239 245.

10. Wonigeit, K. 1979. Characterization of the RT-Ly-1 and RT-Ly-2 alloantigenic systems by congenic rat strains. Transplant. Proc. 11:1631-1635.

11. Gasser, D. L., W. F. Hickey, and N. K. Gonatas. 1983. The genes for nonsusceptibility to EAE in the Le-R and BH rat strains are not linked to RT1. Immunogenetics 17: 441 444.