BDIX

Genotype:

Pigmentation genes: AA BB CC HH PP RR

Mhc: RT1 ^d (RT1.A^dB/D^dC^dv1)

Erythrocyte antigens: RT2 ^b RT8 ^b

Lymphocyte antigens: RT6 ^b RT7 ^a

Inbr. Gen.: At Ztm (1998), F66.

Origin: Druckrey from a cross between BDI and BDVIII with subsequent selection of brother-sister pairs for agouti coat colour and dark, pigmented eyes, to Han in Fx+20 (1979), to Ztm 1994.

Reproduction: Fair reproductive performance; average number weaned per female per week 0.72.

Tumours (Induced): Widely used strain in carcinogenesis and teratogenesis studies. Highly susceptible to transplacental induction of malignant tumours of the nervous system by ethyl nitrosourea (2, 3). Leukemia L5222, a monocytic-myeloid leukemia, which was induced by ethyl nitrosourea, is transplantable and serves as a model for chemotherapy (4).

Other Characteristics: Does not express RT1.B, apparently because it lacks the appropriate structural or controlling gene (6). Hematologic parameters described by Lovell et al. (5) for BDIX/Lac and several other inbred strains.Genetic marker profile described by Bender et al. (1).

References:

1. Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H. J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.

2. Druckrey, H., Ch. Landschütz und S. Ivankovic. 1970. Transplacentare Erzeugung maligner Tumoren des Nervensystems. II. Äthyl-nitrosoharnstoff an 10 genetisch definierten Ratten-stämmen. Z. Krebsforsch. 73: 371 386.

3.Ivankovic, S. and H. Druckrey. 1968. Transplacentare Erzeugung maligner Tumoren des Nervensystems. I. Äthyl-nitroso-harnstoff (ÄNH) an BDIX-Ratten. Z. Krebsforsch. 71: 320 360.

4. Ivankovic, S. and W. J. Zeller. 1974. Leukemia L5222 of the rat strain BDIX. Blut 28: 288 292.

5. Lovell, D. P., R. K. Archer, J. Riley, and R. K. Morgan. 1981. Variation in haematological parameters among inbred strains of rats. Lab. Anim. (London) 15: 243 249.

6. Male, D. K., G. Pryce und G. W. Butcher. 1987. Serological evidence for a defect in RT1.B (I-A) expression by the BDIX rat strain. J. Immunogenet. 14: 301-312.