BDII

Genotype:

Pigmentation genes: aa BB cc hh PP RR

Mhc: RT1 ^u (RT1.A^uB/D^uC^u)

Erythrocyte antigens: RT2 ^a RT8 ^b

Lymphocyte antigens: RT6 ^b RT7 ^b

Inbr. Gen.: At Ztm (1998), F102.

Origin: Druckrey, 1950, from Wistar rats obtained from the Unilever Research Institute, Rotterdam, The Netherlands, to Han, to Ztm 1994.

Reproduction: Fair reproductive performance; average number weaned per female per week 0.85.

Characteristics: Up to 25% of animals are born with microphthalmia or anophthalmia.

Tumours (Spontaneous): In a life-span study with female BDII rats maintained under different conditions the incidence of endometrial carcinomas (mostly adenocarcinomas) was variable 92% in animals fed a purified diet, 90% in conventionally maintained animals, 65% in retired breeders, 58% in germfree rats, and none in ovariectomized animals (2). Genetic marker profile described by Bender et al. (1).

References:

1. Bender, K., P. Balogh, M.F. Bertrand, M. den Bieman, O. van Deimling, S. Eghtessadi, G.A. Gutman, H. J. Hedrich, S.V. Kluge, K. Matsumoto, D.H. Moralejo, M. Nagel, A. Portal, C.-M. Prokop, R.T. Seibert and L.F.M. van Zutphen. 1994. Genetic characterization of inbred strains of the rat (Rattus norvegicus). I. Exp. Anim. Sci. 36: 151-166.

2. Deerberg, F. und J. Kaspareit. 1987. Endometrial carcinoma in BDII/Han rats: Model of a spontaneous hormone-dependent tumor. J. Natl. Cancer Inst. 78: 1245 1251.