Publikationen

 

  

2012

 

Appl H, Holzammer T, Dove S, Haen E, Straßer A, Seifert R. Interactions of recombinant human histamine H₁-, H₂-, H₃- and H₄-receptors with 34 antidepressants and antipsychotics. Naunyn Schmiedebergs Arch Pharmacol 2012; 385: 145-170

 

Beermann S, Glage S, Jonigk D, Seifert R, Neumann D. Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PLoSone 2012; 7: e30285.

 

Beermann S, Seifert R, Neumann D. Commercially available antibodies against human and murine histamine H₄-receptor lack specificity. Naunyn Schmiedebergs Arch Pharmacol 2012; 385: 125-135

 

Beste KY, Burhenne H, Kaever V, Stasch JP, Seifert R. Nucleotidyl cyclase activity of soluble guanylyl cyclase alpha1beta1. Biochemistry 2012; 51: 194-204.

Beste KY, Burkhardt O, Kaever V. Rapid HPL-MS/MS method for simultaneous quantitation of four routinely administered triazole antifungals in human plasma. Clin Chim Acta 2012; 413: 240-245.

 

Birnkammer T, Spickenreither A, Brunskole I, Lopuch M, Kagermeier N, Bernhardt G, Dove S, Seifert R, Elz S, Buschauer A. The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-Type Histamine H₂ Receptor Agonists. J Med Chem 2012 (Epub)

 

Lorenzen JM, Broll M, Kaever V, Burhenne H, Hafer C, Clajus C, Knitsch W, Burkhardt O, Kielstein JT. Pharmacokinetics of Ampicillin/Sulbactam in Critically Ill Patients with Acute Kidney Injury Undergoing Extended Dialysis. Clin J Am Soc Nephrol 2012 (Epub ahead of print).

 

Seifert R, Lushington GH, Mou TC, Gille A, Sprang SR. Inhibitors of membranous adenylyl cyclases. Trends Pharmacol Sci 2012; 33: 64-78

 

Schuler, D, Lübker C, Lushington G, Tang WJ, Shend Y, Richter M, Seifert R. Interactions of Bordetella pertussis Adenylyl Cyclase Toxin CyaA with Calmodulin Mutants and Calmodulin Antagonists: Comparison with Membranous Adenylyl Cyclase I. Biochem Pharmacol 2012 (Epub).

 

Taha H, Dove S, Geduhn J, König B, Shen Y, Tang WJ, Seifert R. Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5’-triphosphates.  Naunyn Schmiedebergs Arch Pharmacol 2012; 385: 57-68.

 

Vauth M, Möhner D, Beermann S, Seifert R, Neumann D. Histamine via the histamine H₂-receptor reduces αCD3-induced IFNγ synthesis in murine CD4⁺ T cells in an indirect manner. J Interf Cytok Res (Epub)

 

 

 

 

2011 

 

Abel S, Chien P, Wassmann P, Schirmer T, Kaever V, Laub MT, Baker TA, Jenal U. Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks. Mol Cell 2001; 43: 550-560.

 

Brunskole I, Strasser A, Seifert R, Buschauer A. Role of the second and third extracellular loops of the histamine H₄ receptor in receptor activation. Naunyn-Schmiedeberg's Arch Pharmacol 2011; 384: 301-317.

 

Büchler G, Wos-Oxley ML, Smoczek A,  Zschemisch NH, Neumann D, Pieper DH, Hedrich HJ, Bleich A. Strain specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactions. Inflamm Bowel Dis 2011 (in press)

 

Burhenne H, Kielstein JT, Burkhardt O, Kaever V. Quantitative analysis of the antifungal drug anidulafungin by LC-online SPE-MS/MS in human plasma. Biomed Chromatogr 2011 [Epub ahead of print]

 

Corrigan RM, Abbott JC, Burhenne H, Kaever V, Gründling A. c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress. PLoS Pathog 2011; 7: e1002217.

 

Dannewitz B, Kruck EM, Staehle HJ, Eickholz P, Giese T, Meuer S, Kaever V, Zeier M, Sommerer C. Cyclosporine-induced gingival overgrowth correlates with NFAT-regulated gene expression: a pilot study. J Clin Periodontol 2011; 38:984-991.

 

Erdorf M, Mou TC, Seifert R. Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs. Biochem Pharmacol 2011; 82: 1673-1681.

 

Erdorf M, Seifert R. Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. Naunyn Schmiedebergs Arch Pharmacol 2011; 338: 357-372.

 

Erdorf M, von der Ohe J, Seifert R. Impaired P2X and P2Y receptor-mediated signaling in HPRT-deficient B103 neuroblastoma cells. Neurosci Lett 2011; 504: 311-315

 

Geduhn J, Dove S, Shen Y, Tang WJ, Konig B, Seifert R. Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis CyaA. J Pharmacol Exp Ther 2011; 336: 104-115.

 

Gudi V, Škuljec J, Yildiz Ö, Frichert K, Skripuletz T, Moharregh-Khiabani D, Voss E, Wissel K, Wolter S, Stangel M. Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming. PLoS One. 2011; 6: e22623

 

Hübner M, Dizayee S, Matthes J, Seifert R, Herzig S. Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol 2011; 383: 573-583.

 

Hübner M, Dixit A, Mou TC, Lushington GH, Pinto C, Gille A, Geduhn J, Konig B, Sprang SR, Seifert R. Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2',3'-O-(N-Methylanthraniloyl)-Inosine 5'-Triphosphate. Mol Pharmacol 2011; 80: 87-96.

 

Kottke T, Sander K, Weizel L, Schneider EH, Seifert R, Stark H. Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H₃/H₄ receptor ligands. Eur J Pharmacol 2011; 654: 200-208. 

 

Omnus DJ, Mehrtens S., Ritter B, Resch K, Yamada M, Frank R, Nourbakhsh M, Reboll MR. JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5′ and 3′ untranslated regions. J Mol Biol 2011; 407: 492-504.

 

Pinto C, Lushington GH, Richter M, Gille A, Geduhn J, König B, Mou TC, Sprang SR, Seifert R. Structure–activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochem Pharmacol 2011; 82: 358-370

 

Pop N, Igel P, Brennauer A, Cabreleb C, Bernhardt G,  Seifert R, Buschauer A. Functional reconstitution of human neuropeptide Y (NPY) Y₂ and Y₄ receptors in Sf9 insect cells. J Recept Signal Transduct 2011; 31: 271-285

 

Reinecke D, Burhenne H, Sandner P, Kaever V, Seifert R. Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated. FEBS Letters 2011; 585: 3259-3262

 

Rhein M, Schwarzer A, Yang M, Kaever V, Brugman M, Meyer J, Ganser A, Baum C, Li Z. Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models. Ann Hematol 2011;90: 283-292. 

 

Ritter B, Kilian P, Reboll MR, Resch K, Distefano JK, Frank R, Beil W, Nourbakhsh M. Differential Effects of Multiplicity of Infection on Helicobacter pylori-Induced Signaling Pathways and Interleukin-8 Gene Transcription. J Clin Immunol 2011; 31: 60-68.

 

Rossbach K, Nassenstein C, Gschwandtner M, Schnell D, Sander K, Seifert R, Stark H, Kietzmann M, Bäumer W. Histamine H₁, H₃ and H₄ receptors are involved in pruritus. Neuroscience 2011; 190: 89-102

 

Schnell D, Brunskole I, Ladova K, Schneider EH, Igel P, Dove S, Buschauer A, Seifert R. Expression und functional properties of canine, rat and murine histamine H₄-receptors in Sf9 insect cells. Naunyn Schmiedebergs Arch Pharmacol 2011; 383: 457-470. 

 

Seifert R, Dove S. Inhibitors of Bacillus anthracis Edema Factor. Curr Pharm Design (Epub).

 

Seifert, R, Dove S. Molecular Analysis of Agonist Stereoisomers at b ₂-Adrenoceptors. In: Drug Stereochemistry: Analytical Methods and Pharmacology (Drugs and the Pharmaceutical Sciences) (Irving W. Wainer, W. J. Lough, Krzysztof Jozwiak, Hrsg.) Informa Healthcare; Auflage: 3rd edition (7th January 2011)

 

 

Seifert R, Schneider EH, Dove S, Brunskole I, Neumann D, Strasser A, Buschauer A. Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: The H₄-receptor joins the club of 7TM receptors exhibiting functional selectivity. Mol Pharmacol 2011; 79: 631-638.

 

Spangler C, Kaever V, Seifert R. Interaction of the di-guanylate cyclase YdeH of Escherichia coli with 2',3'-substituted purine and pyrimidine nucleotides.  J Pharmacol Exp Ther 2011; 336: 234-241.

 

Sutor S, Heilmann J, Seifert R. Impact of fusion to Gα_i2 and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB₁R and CB₂R.  J Pharm Pharmacol 2011; 63: 1043-1055.

 

 

Wiecek M, Kottke T, Ligneau X, Schunack W, Seifert R, Stark H, Handzlik J, Kiec-Kononowicz K. N-Alkenyl and cycloalkyl carbamates as dual acting histamine H₃ and H₄ receptor ligands. Bioorg Med Chem 2011;19: 2850-2858.

 

Wittau M, Scheele J, Bulitta JB, Mayer B, Kaever V, Burhenne H, Henne-Bruns D, Isenmann R, Brockschmidt C. Pharmacokinetics of Ertapenem in Colorectal Tissue. Chemotherapy 2011; 57: 437-448.

 

Wittmann HJ, Elz S, Seifert R, Strasser A. N_α-methylated phenylhistamines exhibit affinity to the hH₄R – a pharmacological and molecular modelling study. Naunyn Schmiedeberg’s Arch Pharmacol 2011; 384: 287-299.

 

 

Wittmann HJ, Seifert R, Strasser A. Influence of the N-terminus and the E₂-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H₁R. Biochem Pharmacol 2011; 82: 1910-1918.

 

Wölbeling F, Munder A, Kerber-Momot T, Neumann D, Hennig C, Hansen G, Tümmler B, Baumann U. Lung function and inflammation during murine Pseudomonas aeruginosa airway infection. Immunobiology 2011; 216: 901-908.

 

Wolter S, Golombek M, Seifert R. Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides. Biochem Biophys Res Commun 2011; 415: 563-566.

  

Zimmermann S, Burhenne H, Kaever V, Seifert R, Neumann D. Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains, C57Bl/6 and Balb/c. Inflamm Res 2011; 60: 1153-1159.
 

2010

 

Boehm A, Kaiser M, Li H, Spangler C, Kasper C, Ackermann M, Kaever V, Sourjik V, Roth V, Jenal U. Second messenger-mediated adjustment of bacterial swimming velocity. Cell 2010; 141: 107-116.

 

Desch M, Schinner E, Kees F, Hofmann F, Seifert R, Schlossmann J. Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I. FEBS Lett 2010; 584: 3979-3984.

 

Emmrich T, El-Tayeb A, Taha H, Seifert R, Müller CE, Link A. Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases. Bioorg. Med Chem Lett 2010; 20: 232-235. 

 

Geiger S, Nickl K, Schneider EH, Seifert R, Heilmann J.  Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands. Naunyn Schmiedebergs Arch Pharmacol 2010; 382: 177-191.

 

Ghorai P, Kraus A, Birnkammer T, G eyer R, Bernhardt G, Dove S, Seifert R.  Chiral N^G-acylated hetarylpropylguanidine-type histamine H₂ receptor agonists do not show significant stereoselectivity. Bioorg Med Chem Lett 2010; 20: 3173-3176.

 

Göttle M, Dove S, Kees F, Schlossmann J, Geduhn J, König B, Shen Y, Tang WJ, Kaever V, Seifert R. Cytidylyl- and uridylyl cylcase activtiy of bacillus anthracis edema factor and bordetella pertussis CyaA. Biochemistry 2010; 49: 5494-5503.

 

Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A. Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix. Rapid Commun Mass Spectrom 2010; 24: 561-70.

 

Malone JG, Jaeger T, Spangler C, Ritz D, Spang A, Arrieumerlou C, Kaever V, Landmann R, Jenal U. YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa. PLoS Pathog 2010; 6: e1000804.

 

Nachtigall J, Schulz D, Beil W, Süssmuth RD, Fiedler HP.  Aranciamycin anhydride, a new anthracycline-type antibiotic isolated from Streptomyces sp. Tü 6384(*). Antibiot (Tokyo) 2010; 63: 397-399.

 

Neumann D, Beermann S, Seifert R. Does the histamine H₄ receptor have a pro- or anti-inflammatory role in murine bronchial asthma? Pharmacology 2010; 85: 217-223.

 

Resch K, Martin M, Kaever V. Immunpharmakologie. UTB, Stuttgart 2010. 1. Auflage. 299 Seiten. ISBN: 978-3-8252-8436-7.

 

Sander K, Kottke T, Hoffend C, Walter M, Weizel L, Camelin JC, Ligneau X, Schneider EH, Seifert R, Schwartz JC, Stark H. First metal-containing histamine H₃ receptor ligands. Org Lett 2010; 12:2578-2581.

 

Schneider EH, Schnell D, Strasser A, Dove S, Seifert R. Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein-Coupling of the Human Histamine H₄ Receptor. J Pharmacol Exp Ther 2010; 333: 282-292.

 

Schneider EH, Seifert R. Sf9 cells: A versatile model system to investigate the pharmacological properties of G protein-coupled receptors. Pharmacol Ther  2010; 128: 387-418.

 

Schneider EH, Seifert R. Coexpression Systems as Models for the Analysis of Constitutive GPCR Activity. Methods Enzymol 2010; 485: 527-57.

 

Schneider EH, Seifert R. Fusion Proteins as Model Systems for the Analysis of Constitutive GPCR Activity. Methods Enzymol 2010; 485:459-80.

 

 

Schneider EH, Strasser A, Thurmond RL, Seifert R. Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole- and thienopyrrole histamine H₄R ligands. J Pharmacol Exp Ther 2010; 334: 513-521.

 

Schnell D, Burleigh K, Trick J, Seifert R. No evidence for functional selectivity of proxyfan at the human histamine H₃-receptor coupled to defined G_i/G_o protein heterotrimers. J Pharmacol Exp Ther 2010; 332: 996-1005.

 

Schnell D, Seifert R. Modulation of histamine H₃ receptor function by monovalent ions. Neurosci Lett 2010; 472; 114-118.

 

Schnell D, Strasser A, Seifert R.  Comparison of the pharmacological properties of human and rat histamine H₃-receptors. Biochem Pharmacol 2010; 80: 1437-1449.

 

Spangler C, Boehm A,  Jenal U, Seifert R, Kaever V. A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphates. J Microbiol Methods 2010; 81: 226-231. 

 

 

 

2009

 

Burkhardt O, Ellis S, Burhenne H, Kaever V, Hadem J, Kielstein JT, Welte T. High caspofungin levels in alveolar cells of a lung transplant patient with suspected pulmonary aspergillosis. Int J Antimicrob Agents 2009; 34: 491-492.

 

Burkhardt O, Hafer C, Langhoff A, Kaever V, Kumar V, Welte T, Haller H, Fliser D, Kielstein JT. Pharmacokinetics of ertapenem in critically ill patients with acute renal failure undergoing extended daily dialysis. Nephrol Dial Transplant 2009; 24: 267-271

 

Burkhardt O, Kaever V, Burhenne H, Kielstein JT. Extended daily dialysis does not affect the pharmacokinetics of anidulafungin. Int J Antimicrob Agents 2009; 34: 282-283

 

Burkhardt O, Rauch K, Kaever V, Hadem J, Kielstein JT, Welte T. Tigecycline possibly underdosed for the treatment of pneumonia: a pharmacokinetic viewpoint. Int J Antimicrob Agents 2009; 34:101-102

 

Deml KF, Beermann S, Neumann D, Strasser A, Seifert R. Interactions of Histamine H₁-Receptor Agonists and Antagonists with the Human Histamine H₄-Receptor. Mol Pharmacol 2009; 76: 1019-1030

 

Egger M, Maity P, Hübner M, Seifert R, König B. Synthesis and pharmacological properties of new tetracyclic forskolin analogues. Eur J Org Chem 2009; 3613-3618

 

Favilli F, Anzilotti C, Martinelli L, Quattroni P, De Martino S, Pratesi F, Neumann D, Beermann S, Novick D, Dinarello CA, Boraschi D, Migliorini P. IL-18 activity in systemic lupus erythematosus. Ann N Y Acad Sci 2009; 1173: 301-309

 

Göttle M, Geduhn J, Konig B, Gille A, Hocherl K, Seifert R. Characterization of mouse heart adenylyl cyclase. J Pharmacol Exp Ther 2009; 329: 1156-1165

 

Hohmann C, Schneider K, Bruntner C, Irran E, Nicholson G, Bull AT, Jones AL, Brown R, Stach JE, Goodfellow M, Beil W, Krämer M, Imhoff JF, Süssmuth RD, Fiedler HP. Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*). J Antibiot (Tokyo) 2009; 62: 99-104

 

Holstein A, Beil W. Oral antidiabetic drug metabolism: pharmacogenomics and drug interactions. Expert Opin Drug Metab Toxicol 2009; 5: 225-241

 

Igel P, Geyer R, Strasser A, Dove S, Seifert R, Buschauer, A. Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H₄ Receptor Agonists. J. Med. Chem 2009; 52: 5297-5313 

 

Igel P, Schneider E, Schnell D, Elz S, Seifert R, Buschauer A. N^G-Acylated Imidazolylpropylguanidines as Potent Histamine H₄ Receptor Agonists: Selectivity by Variation of the N^G-Substituent. J Med Chem 2009; 52: 2623-2627

 

Igel P, Schnell D, Bernhardt G, Seifert R, Buschauer A. Tritium-labeled N¹-[3-(1H-imidazol-4-yl)propyl]-N²-propionylguanidine ([³H]UR-PI294), a high-affinity histamine H₃ and H₄ receptor radioligand. ChemMedChem 2009; 4: 225-231

 

Kielstein JT, Lorenzen J, Kaever V, Burhenne H, Broll M, Hafer C, Burkhardt O. Risk of underdosing of ampicillin/sulbactam in patients with acute kidney injury undergoing extended daily dialysis - a single case. Nephrol Dial Transplant 2009 24:2283-2285

 

Kraus A, Ghorai P, Birnkammer T, Schnell D, Elz S, Seifert R, Dove S, Bernhardt G, Buschauer A. N^G-acylated aminothiazolylpropylguanidines as potent and selective histamine H₂ receptor agonists. ChemMedChem 2009; 4: 232-240

 

Kruse B, Thissen S, Warnecke G, Avsar M, Gottlieb J, Hohlfeld JM, Karstens JH, Kaever V, Länger F, Pabst B, Ungefroren H, Haverich A, Strüber M. Correlation of donor leukocyte chimerism with pulmonary allograft survival after immunosuppressive drug withdrawal in a porcine model. Transplantation 2009; 87: 1468-1477

 

Łazewska D, Wiecek M, Ligneau X, Kottke T, Weizel L, Seifert R, Schunack W, Stark H, Kiec-Kononowicz K. Histamine H₃ and H₄ receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorg. Med. Chem. Lett. 2009; 19: 6682-6685.

 

Pinto C, Hübner M, Gille A, Richter M, Mou TC, Sprang SR, Seifert R. Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs. Biochem Pharmacol 2009; 78: 62-69

 

Sander K, Kottke T, Tanrikulu Y, Proschak E, Weizel L, Schneider EH, Seifert R, Schneider G, Stark H. 2,4-Diaminopyrimidines as histamine H₄ receptor ligands-Scaffold optimization and pharmacological characterization. Bioorg Med Chem 2009; 17: 7186-7196

 

Schneider EH, Schnell D, Papa D, Seifert R. High constitutive activity and a G-protein-independent high-affinity state of the human histamine H₄-receptor. Biochemistry 2009; 48: 1424-38

 

Schneider EH, Seifert R. Histamine H₄ receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H₄ receptor ligands. Biochem Pharmacol 2009; 78: 607-616

 

Schulz D, Nachtigall J, Riedlinger J, Schneider K, Poralla K, Imhoff JF, Beil W, Nicholson G, Fiedler HP, Süssmuth RD. Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2. J Antibiot (Tokyo) 2009; 62: 513-8

 

Seifert R, Dove S, Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities. Mol Pharmacol 2009; 75: 13-18

 

Strasser A, Wittmann HJ, Kunze M, Elz S, Seifert R. Molecular basis for the selective interaction of synthetic agonists with the human histamine H₁-receptor compared with the guinea pig H₁-receptor. Mol Pharmacol 2009; 75: 454-465

 

Suryanarayana S, Göttle M, Hübner M, Gille A, Mou TC, Sprang SR, Richter M, Seifert R. Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates. J Pharmacol Exp Ther 2009; 330: 687-695

 

Suryanarayana S, Pinto C, Mou TC, Richter M, Lushington GH, Seifert R. The C1 Homodimer of Adenylyl Cyclase Binds Nucleotides with High Affinity but Possesses Exceedingly Low Catalytic Activity. Neurosci Lett. 2009; 467: 1-5

 

Suryanarayana S, Wang JL, Richter M, Shen Y, Tang WJ, Lushington GH, Seifert R. Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor. Biochem Pharmacol 2009; 78: 224-230

 

Taha HM, Schmidt J, Göttle M, Suryanarayana S, Shen Y, Tang WJ, Gille A, Geduhn J, König B, Dove S, Seifert R. Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides. Mol Pharmacol 2009; 75: 693-703

 

Tanrikulu Y, Proschak E, Werner T, Geppert T, Todoroff N, Klenner A, Kottke T, Sander K, Schneider E, Seifert R, Stark H, Clark T, Schneider G. Homology model adjustment and ligand screening with a pseudoreceptor of the human histamine H₄ receptor. ChemMedChem 2009; 4: 820-827

 

Warnecke G, Hutchinson JA, Riquelme P, Kruse B, Thissen S, Avsar M, Zehle G, Steinkamp T, Peters C, Baumann R, Govert F, Ungefroren H, Länger F, Simon AR, Karstens JH, Kaever V, Haverich A, Fandrich F, Strüber M. Postoperative intravenous infusion of donor-derived transplant acceptanceinducing cells as an adjunct immunosuppressive therapy in a porcine pulmonary allograft model. Transpl Int 2009; 22: 332-341

 

Wittmann HJ, Seifert R, Strasser A. Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea-pig histamine H₁-receptor. Mol Pharmacol 2009; 76: 25-37 

 

 

2008

 

Bakker H, Routier F, Ashikov A, Neumann D, Bosch D, Gerardy-Schahn R. A CMP-sialic acid transporter cloned from Arabidopsis thaliana. Carbohydr Res 2008; 343: 2148-2152

 

Deters M, Knochenwefel H, Lindhorst D, Koal T, Meyer HH, Hänsel W, Resch K, Kaever V. Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities. Pharm Res 2008; 25: 1822-1827

 

Dove S, Seifert R, Elz S, Buschauer A. Frontiers in medicinal chemistry in Regensburg. ChemMedChem 2008; 3: 1181-1184

 

Egger M, Pellett P, Nickl K, Geiger S, Graetz S, Seifert R, Heilmann J, König B. Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues. Chemistry 2008; 14: 10978-10984

 

Fiedler HP, Bruntner C, Riedlinger J, Bull AT, Knutsen G, Goodfellow M, Jones A, Maldonado L, Pathom-aree W, Beil W, Schneider K, Keller S, Sussmuth RD. Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora.  J Antibiot (Tokyo). 2008; 61: 158-163

 

Ghorai P, Kraus A, Keller M, Götte C, Igel P, Schneider E, Schnell D, Bernhardt G, Dove S, Zabel M, Elz S, Seifert R, Buschauer A. Acylguanidines as bioisosteres of guanidines: N^G-acylated imidazolylpropylguanidines, a new class of histamine H₂ receptor agonists. J Med Chem 2008; 51: 7193-7204

 

Hartwig C, Constabel H, Neumann D, Gerd Hoymann H, Tschernig T, Behrens GM. Impact of boostering for the strength of asthma parameters and dendritic cell numbers in a C57BL/6 model of allergic airway inflammation. Exp Toxicol Pathol 2008; 60: 425-434

 

Hartwig C, Tschernig T, Mazzega M, Braun A, Neumann D. Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms. Cytokine 2008; 42: 298-305

 

Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M. Transcriptional regulation of EGR-1 by the Interleukin-1-JNK-MKK7-c-JUN pathway. J Biol Chem 2008; 283: 12120-12128

 

Kleemann P., Papa D., Vigil-Cruz S., Seifert R. Functional reconstitution of the human chemokine receptor CXCR4 with G_i/G_o-proteins in Sf9 insect cells. Naunyn Schmiedeberg’s Arch Pharmacol 2008: 378; 261-274

 

Neumann D, Kollewe C, Pich A, Cao P, Resch K, Martin MU. Threonine 66 in the death domain of IRAK-1 is critical for interaction with signalling molecules but is not a target site for autophosphorylation. J Leukoc Biol 2008; 84: 807-813

 

Nickl K, Gardner EE, Geiger S, Heilmann J, Seifert R. Differential coupling of the human cannabinoid receptors hCB₁R and hCB₂R to the G-protein Galpha_i2beta₁gamma₂. Neurosci Lett 2008; 447: 68-72

 

Pinto C, Papa D, Hübner M, Mou TC, Lushington GH, Seifert R. Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs. J Pharmacol Exp Ther 2008; 325: 7-36

 

Rohdewald P, Beil W. In vitro inhibition of Helicobacter pylori growth and adherence to gastric mucosal cells by Pycnogenol. Phytother Res 2008; 22: 685-688

 

Schneider K, Keller S, Wolter FE, Röglin L, Beil W, Seitz O, Nicholson G, Bruntner C, Riedlinger J, Fiedler HP, Süssmuth RD. Proximicins A, B, and C-antitumor furan analogues of netropsin from the marine actinomycete Verrucosispora induce upregulation of p53 and the cyclin kinase inhibitor p21. Angew Chem Int Ed Engl 2008; 47: 3258-3261

 

Sommer PS, Almeida RC, Schneider K, Beil W, Süssmuth RD, Fielder HP. Nataxazole, a new benzoxazole derivative with antitumor activity produced by Streptomyces sp. Tü 6176.  J Antibiot (Tokyo). 2008 Nov; 61: 683-686

 

Spangler CM, Spangler C, Göttle M, Shen Y, Tang WJ, Seifert R, Schäferling M. A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin. Anal Biochem. 2008; 381: 86-93

 

Strasser A, Wittmann HJ, Seifert R. Ligand-specific contribution of the N terminus and E2-loop to pharmacological properties of the histamine H₁-receptor. J Pharmacol Exp Ther 2008; 326: 783-791. 

 

Strasser A., Striegl B., Wittmann H. J., Seifert R. Pharmacological profile of histaprodifens at four recombinant histamine H₁ receptor species isoforms. J. Pharmacol Exp Ther 2008; 324: 60-71

 

Tschernig T, Neumann D, Pich A, Dorsch M, Pabst R. Experimental bronchial asthma - the strength of the species rat. Curr Drug Targets 2008; 9: 466-469

 

Weitl N, Seifert R. Distinct interactions of human beta₁- and beta₂-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine. J Pharmacol Exp Ther. 2008; 327: 760-769

 

Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M. c-Jun controls histone modifications, NF-kappaB recruitment and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol 2008; 28: 4407-4423