AG Limbourg
Research Group Regenerative Agents-
Excellence Cluster REBIRTH
Group leader:
Dr. Florian P. Limbourg
Tel. +49 511-532-5302
Fax +49 511-532-5307
limbourg.florian
mh-hannover.de
Open positions:
We offer state of the art thesis projects to talented and highly engaged students. Please call for further details.
Postdoctoral Scientist Position at Hannover Medical School - Excellence Cluster REBIRTH
The Junior Research Group "Regenerative Agents" is recruiting a highly motivated and ambitious postdoctoral scientist, ideally with a strong research background in immunology, molecular biology or developmental biology.
We are focusing on regulation of cell fate by Notch signaling during adult cardiovascular regeneration. Of particular interest is the role of Notch signaling in arteries and bone marrow-derived cell populations. The full-time position (TV-L E13) is available starting 4/09 or later. We are an equal opportunity employer.
Please address inquiries and applications (CV, publications, names of referees in single pdf file) to:
Dr. Florian P. Limbourg
limbourg.florianmh-hannover.de
phone: +49 511 532 5302.
Research focus:
We are studying the re-emergence of developmental genetic programs regulating cell fate decisions during adult cardiovascular regeneration. Of particular interest is the evolutionary conserved Notch signalling pathway, which plays an important role in embryonic organ development but its role in postnatal regeneration remains largely unknown.
Current projects focus on
- the regulation of vascular differentiation and arterial growth (arteriogenesis)
- the regulation of vascular and resident cardiac progenitor cell differentiation
- the role of Notch signalling in cardiac repair
Our aim is to improve cardiovascular regeneration by targeted manipulation of cardiovascular differentiation.
The Research Group "Regenerative Agents" is located at the Dept. of Cardiology at Hannover Medical School and embedded in the Cluster of Excellence "From Regenerative Biology to Reconstructive Therapy" (REBIRTH). Our campus provides an international and dynamic research environment with several international PhD programs at Hannover Biomedical Research School associated with Hannover Medical School.
Group members:
Florian P. Limbourg, Dr. med.
limbourg.florianmh-hannover.de
phone +49-511/532-5302
Anne Limbourg. Dr. med.
phone +49-511/532-5301
L. Christian Napp, Dr. med.
phone +49-511/532-5340
Jeannette Woiterski, MSc
phone +49-511/532-5341
Sabine Schnabel, cand. vet.
phone +49-511/532-5348
Lian Hu, Dr. dent.
phone +49-511/532-5344
Kashyap Krishnasamy, MSc
krishnasamy.kashyapmh-hannover.de
phone +49-511/532-5344
Maryam Saghafian
saghafian.maryammh-hannover.de
phone +49-511/532-5341
Lab adress:
Hannover Medical School
Molecular Cardiology OE 6889
K11 Level S0
Carl-Neuberg-Str. 1
30625 Hannover
Germany
Awards:
2007 American Heart Association Merit Award for Young Investigators (to LCN)
2007 Rudolf Thauer Poster Award German Society of Cardiology (DGK) (to AL)
2002 American College of Cardiology Young Investigator Award (to FPL)
2000 Young Investigator Award, Deutsche Hochdruckliga (to FPL)
Selected publications
Sorrentino SA, Bahlmann FH, Besler C, Müller M, Schulz S, Kirchhoff N, Doerries C, Horváth T, Limbourg A, Limbourg F, Fliser D, Haller H, Drexler H, Landmesser U 2007: Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation 116(2):163-73.
Limbourg A, Ploom M, Elligsen D, Sörensen I, Ziegelhoeffer T, Gossler A, Drexler H, Limbourg FP 2007: Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res 100(3):363-71.
Takeshita K, Satoh M, Ii M, Silver M, Limbourg FP, Mukai Y, Rikitake Y, Radtke F, Gridley T, Losordo DW, Liao JK 2007: Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res 100(1):70-8.
Templin C, Kotlarz D, Marquart F, Faulhaber J, Brendecke V, Schaefer A, Tsikas D, Bonda T, Hilfiker-Kleiner D, Ohl L, Naim HY, Foerster R, Drexler H, Limbourg FP 2006: Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: feasibility, cellular kinetics, and improvement in cardiac function. Basic Res Cardiol 101(4):301-10.
Limbourg FP, Ringes-Lichtenberg S, Schaefer A, Jacoby C, Mehraein Y, Jäger MD, Limbourg A, Fuchs M, Klein G, Ballmaier M, Schlitt HJ, Schrader J, Hilfiker-Kleiner D, Drexler H 2005: Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment. Eur J Heart Fail 7(5):722-9.
Limbourg FP, Takeshita K, Radtke F, Bronson RT, Chin MT, Liao JK 2005: Essential role of endothelial Notch1 in angiogenesis. Circulation 111(14):1826-32.
Limbourg FP, Drexler H : 2005: Bone marrow stem cells for myocardial infarction: effector or mediator? Circ Res. 2005 Jan 7;96(1):6-8.
Limbourg FP, Huang Z, Plumier JC, Simoncini T, Fujioka M, Tuckermann J, Schütz G, Moskowitz MA, Liao JK 2002: Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest 110(11):1729-38.
Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK 2002: Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 8(5):473-9.
